Results 51 to 60 of about 1,598 (268)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Mediación parental del uso de Internet desde una perspectiva de género.

Revista Electrónica de Investigación Educativa, 2020
El objetivo de esta investigación es conocer la percepción de los progenitores sobre el uso de Internet de sus hijos/as, así como sus prácticas de mediación para promover los beneficios y evitar los riesgos en la red.
Isabel Bartau Rojas, Ana Aierbe Barandiaran, Eider Oregui Gonzalez   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

P1569: COVID19 AND ITS IMPACT ON HEMATO-ONCOLOGICAL PATIENTS. DIFFERENCES IN OUTCOMES IN RELATION TO OMICRON CIRCULATION AND VACCINATION STATUS?

HemaSphere, 2022
A. Addiego, A. I. Prado, V. Moraes, P. Cano, I. Gervaz, L. Perez, R. De Giuda, A. Flores, E. Riva, M. Ferrando, S. Grille, G. Borelli, A. Vazquez, M. Stevenazzi, R. Gabus, A. I. Landoni, C. Guillermo, M. Boada   +17 more
doaj   +1 more source

Acerca del híbrido Sideritis ×pertegasii, nothosp. nov. (Labiatae)

Collectanea Botanica, 2018
Se describe el híbrido Sideritis ×pertegasii recolectado por Pau, interpretando su origen como producto del cruzamiento entre S. spinulosa subsp. subspinosa y S. tragoriganum subsp. juryi (Labiatae). Se presenta una descripción morfológica, una tabla con
R. Roselló, P. P. Ferrer-Gallego, J. Gómez, E. Laguna, J. B. Peris   +4 more
doaj   +1 more source

GRB Progenitors and Environment

Il Nuovo Cimento C, 2005
Invited review at the 4th Workshop Gamma-Ray Bursts in the Afterglow Era, Rome,18-22 October 2004. Editors: L. Piro, L. Amati, S. Covino, and B. Gendre.
openaire   +2 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Melanoma in prepuberal children: Diagnostic and therapeutic challenges

Anales de Pediatría (English Edition), 2022
Cristina Larrosa, Antonio Torrelo, Luis Madero, Álvaro Lassaletta   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source