Results 121 to 130 of about 17,639 (297)
Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins [PDF]
, 2011 Spatial and temporal organization of the genome represents an additional step in the regulation of nuclear functions. The nuclear lamina, a polymeric meshwork formed by lamins (A/C and B type) and lamin-associated proteins, plays a key role in the ...
Gonzalez-Suarez, Ignacio +2 more
core +2 more sources
Circular RNA Telomerase Reverses Endothelial Senescence in Progeria
Aging Cell, Volume 24, Issue 6, June 2025.TERT circRNA outperforms linear TERT mRNA in reversing the hallmarks of senescence. TERT circRNA more efficiently restores endothelial function and shows superior capability in enhancing mitochondrial function. ABSTRACT Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells,
Weifeng Qin +6 more
wiley +1 more source
Саратовский научно-медицинский журнал, 2014 The data of literature, reflecting etiology, clinical features and differential diagnosis of progeria of childhood and adult are ...
Utz S.R. +3 more
doaj
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
MedComm, Volume 6, Issue 5, May 2025.ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen +5 more
wiley +1 more source
A Rare Case of Hutchınson-Gılford Progerıa Syndrome wıth Early Dental Loss wıthout Decay
Makara Journal of Health Research, 2018 Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal recessive genetic disorder that occurs as a point mutation in the LMNA gene. It is a rare hereditary disorder, with approximately 100 cases reported in the medical literature. These patients
Tuğçe N. Pekdemir +6 more
doaj +1 more source
Accumulation of prelamin A compromises NF-kB-regulated B-lymphopoiesis in progeria mouse model. [PDF]
, 2013 published_or_final_versio
Liu, B +5 more
core +1 more source
Aging Cell, Volume 24, Issue 5, May 2025.We created an inducible system to control the expression of p16, and found that tau phosphorylation was enhanced upon p16 up‐regulation in neurons differentiated from human iPSCs. As p16 expression is increased during aging, our findings suggest a possible role of age‐associated p16 up‐regulation in Alzheimer's disease. As pathological tau tangles have
Kristopher Holloway +7 more
wiley +1 more source
Iatreia, 2010 INTRODUCCIÓN : mutaciones en el gen LMNA, LAMINA A/C; originan un grupo de desordenes genéticos que pueden ser clasificados en cuatro grupos: enfermedades de músculo estriado y cardiaco, síndromes lipodistroficos, neuropatías periféricas y progeria (1 ...
Lucero Tarin A. +2 more
doaj
International Journal of Medical Students, 2015 Genetic mutations are becoming more deleterious day by day. Mutations of Genes named FBN1, AKT1, LMNA result specific protein malfunction that in turn commonly cause Marfan syndrome, Proteus syndrome, and Progeria, respectively.
Tonmoy Biswas
doaj +1 more source
The thermodynamics of metabolism, cardiovascular performance and exercise, in health and diabetes: The objective of clinical markers [PDF]
, 2013 Extensive experience in UK National Health Service metabolic syndrome/type 2 diabetes clinics highlights the need for convenient clinical marker(s) which can be readily used to indicate the success or otherwise of alternative therapies.
Atherton, MA +4 more
core