Results 101 to 110 of about 14,020 (216)

DNA damage: A main determinant of vascular aging [PDF]

, 2016
Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of ...
Bautista-Niño, P.K. (Paula), Danser, A.H.J. (Jan), Portilla-Fernandez, E. (Eliana), Roks, A.J.M. (Anton), Vaughan, D.E. (Douglas E.)   +4 more
core   +2 more sources

Current advances and future prospects of cell reprogramming in progeroid syndromes

Frontiers in Cell and Developmental Biology
Cell reprogramming consists in the reverse process to cell differentiation, making cells lose their identity and age-related characteristics and granting an increased potential for proliferation and redifferentiation on different lineages.
Lucas Moledo-Nodar, Víctor Celemín-Capaldi, Alejandro P. Ugalde, Alejandro P. Ugalde, José M. P. Freije, José M. P. Freije, José M. P. Freije   +6 more
doaj   +1 more source

Mutation in Genes FBN1, AKT1, and LMNA: Marfan Syndrome, Proteus Syndrome, and Progeria Share Common Systemic Involvement

International Journal of Medical Students, 2015
Genetic mutations are becoming more deleterious day by day. Mutations of Genes named FBN1, AKT1, LMNA result specific protein malfunction that in turn commonly cause Marfan syndrome, Proteus syndrome, and Progeria, respectively.
Tonmoy Biswas
doaj   +1 more source

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

EMBO Molecular Medicine, 2019
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we demonstrated that
Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés   +9 more
doaj   +1 more source

Hutchinson-Gilford Progeria as a Window into Human Aging: Genetic, Cellular, and Therapeutic Perspectives

Medicina U.P.B.
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare and devastating genetic disorder characterized by premature aging. This condition is caused by an autosomal dominant mutation in the LMNA gene, which leads to the production of the defective protein ...
María Elena Arana Baquero, Camilo Andrés Yidi de Vivo, Isabella Santodomingo Vásquez   +2 more
doaj   +1 more source

Yawkey Foundations 2010 Grants Report [PDF]

, 2011
Contains mission statement, board chair and president's message; grantee profiles in the areas of health, education, and human services; 2010 grants list and highlights; grant guidelines; and list of board ...

core  

Vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells [PDF]

, 2014
To study the vulnerability of smooth muscle cells (SMCs) in Hutchinson-Gilford Progeria Syndrome (HGPS)
Ferreira, Lino, Nissan, Xavier, Pitrez, Patricia R., Rocha, I., Vazão, Helena   +4 more
core  

Congenital entropion with progeria: 4 going 40

Indian Journal of Ophthalmology, 2022
Himika Gupta, Suhas Pawar
doaj   +1 more source

The hallmarks of aging as a conceptual framework for health and longevity research

Frontiers in Aging
The inexorability of the aging process has sparked the curiosity of human beings since ancient times. However, despite this interest and the extraordinary scientific advances in the field, the complexity of the process has hampered its comprehension.
Antonio G. Tartiere, José M. P. Freije, José M. P. Freije, Carlos López-Otín, Carlos López-Otín, Carlos López-Otín   +5 more
doaj   +1 more source

PROGERIA SYNDROME [PDF]

Medical Journal Armed Forces India, 1999
openaire   +2 more sources