Results 121 to 130 of about 9,936 (203)

Progeria [PDF]

, 2019
openaire   +1 more source

Mutation-agnostic base editing of the progerin farnesylation site rescues Hutchinson-Gilford progeria syndrome phenotypes in neuromuscular organoids. [PDF]

Nat Commun
Kim DW, Kwon EJ, Jeon BJ, Kwon DH, Jang G, Yoon Y, Hwang Y, Lee H, Cha HJ.   +8 more
europepmc   +1 more source

TRF2 enriched cytoplasmic chromatin drives cGAS-STAT1-mediated inflammation in senescence. [PDF]

iScience
Kandhaya-Pillai R, Kim HY, Belhadj J, Sidorova JM, Tchkonia T, Kirkland JL, Oshima J.   +6 more
europepmc   +1 more source

Lamin-ating the genome: quantitative gatekeeping of replication initiation. [PDF]

Trends Cell Biol
Parasar B, Moghadami S, Tan L.
europepmc   +1 more source

Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response. [PDF]

J Orthop Res
Duke VR, Philippon MJ, Lind DRG, Kasler H, Yamaura K, Huard M, Czachor M, Hollenbeck J, Brown J, Garcia A, Matityahu JD, Fukase N, Marcucio RS, Nelson AL, Hambright WS, Snapper DM, Huard J, Bahney CS.   +17 more
europepmc   +1 more source

Abnormal Myocardial Deformation Despite Normal Ejection Fraction in Hutchinson‐Gilford Progeria Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Flemming J. Olsen, Tor Biering‐Sørensen, Fatima Lunze, Sheila M. Hegde, Steven D. Colan, Rachel Ehrbar, Joseph Massaro, Alessandra M. Ferraro, David M. Harrild, Monica E. Kleinman, Leslie B. Gordon, Ashwin Prakash   +11 more
doaj   +1 more source

In Vivo Base Editing for Neonatal Inborn Errors of Metabolism: Clinical Progress, N-of-1 Therapy, and the Ethics of Bespoke Genetic Medicine. [PDF]

Cureus
Li OM, Li Y, Li SXT.
europepmc   +1 more source

New approaches to progeria

Progeria (Hutchinson-Gilford progeria syndrome) is a rare genetic disorder that offers considerable insight into the biology of premature aging. This review summarizes the clinical characteristics of this disease and the underlying mutation in the lamin ...
Kieran, Mark W.
core  

Excessive disulfide bonds in lamin A/C contribute to premature human aging. [PDF]

Mol Cells
Ha SG, Park M, Lee J, Bong D, Ahn J, Kim D, Kim MO, Lee SV, Ha NC.   +8 more
europepmc   +1 more source

Barrier-to-Autointegration Factor 1: a key regulator of nuclear envelope integrity, genome stability, and disease progression. [PDF]

Front Immunol
Shi P, Wang S, Zang Z, Wang D, Yang C, Tao J, Liu J, Sun J, Shen W, Wang R, Sun M.   +10 more
europepmc   +1 more source