Results 81 to 90 of about 14,020 (216)
Indian journal of dermatology, venereology and leprology, 2017 A year old male child developed progeria manifesting most of the typical changes described in progeria. The boy also had extensive sclerodermatous changes in the skin.
R P C, Naik, E P, Eapen, B, Joseph
openaire +3 more sources
Accumulation of prelamin A compromises NF-kB-regulated B-lymphopoiesis in progeria mouse model. [PDF]
, 2013 published_or_final_versio
Liu, B +5 more
core +1 more source
SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling
Aging Cell, Volume 25, Issue 2, February 2026.SIRT6 regulates proteostasis through nucleolar regulation. SIRT6 regulates (A) pre‐rRNA editing through nucleolar factors, as well as (B) rRNA transcription through TIP5 – and thus the NoRC – chromatin recruitment. (C) Once SIRT6 is depleted, the rRNA production and editing are increased, leading to a dramatic elevation in translation rates.
Daniel Stein +13 more
wiley +1 more source
Iatreia, 2010 INTRODUCCIÓN : mutaciones en el gen LMNA, LAMINA A/C; originan un grupo de desordenes genéticos que pueden ser clasificados en cuatro grupos: enfermedades de músculo estriado y cardiaco, síndromes lipodistroficos, neuropatías periféricas y progeria (1 ...
Lucero Tarin A. +2 more
doaj
Age-dependent changes of nuclear morphology are uncoupled from longevity in Caenorhabditis elegans IGF/insulin receptor daf-2 mutants [PDF]
, 2016 Nuclear envelope (NE) architecture and aging have been associated since the discovery that certain human progeria diseases are due to perturbations in processing of lamin A protein, generating alterations in NE morphology. However, whether changes in the
Askjaer, Peter +4 more
core +1 more source
Revista chilena de pediatría, 2002 Resumen La progeria o síndrome de Hutchinson-Gilford esun síndrome poco frecuente. Consiste en la aparición de signos de envejecimiento en niños entre su primer y segundo año de vida. La mayoría de los casos de progeria son esporádicos, lo cual plantea la posibilidad de un patrón de herencia autosómico dominante por mutación de novo.
Pardo V., Rosa Andrea +1 more
openaire +2 more sources
Aging Cell, Volume 25, Issue 2, February 2026.Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell +9 more
wiley +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.Young multipotent muscle‐derived stem/progenitor cells (MDSPCs) secrete a unique profile of pro‐angiogenic and immunomodulatory proteins that are diminished with age. Systemic transplantation of young MDSPCs into naturally aged mice activates pathways in neuromuscular tissues, enhancing health and driving molecular, structural, and functional ...
Seth D. Thompson +5 more
wiley +1 more source
Mechanobiology of the Nucleolus
Biology of the Cell, Volume 118, Issue 2, February 2026.Mechanical forces reshape nuclear structure and reorganize the nucleolus, altering its role in ribosome biogenesis. This review examines how mechanical cues impact nucleolar assembly and function. We propose that the nucleolus acts as a mechano‐responsive condensate integrating mechanical stress with cellular homeostasis.
Yuthika Shetty, Monika Elzbieta Dolega
wiley +1 more source
Posttranslational Modifications of Lamin A/C and Cardiac Aging: A Short Review
Journal of the Practice of Cardiovascular SciencesCardiac aging is considered as natural and age-related changes in the heart, which can lead to a decline in heart function. Cardiac aging increases the risk of heart failure, atrial fibrillation, and other cardiovascular complications.
Vikas Tiwari +2 more
doaj +1 more source