Results 71 to 80 of about 17,639 (297)

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]

, 2016
Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P, Gault, Joseph, Marcoux, Julien, Mehmood, Shahid, Michaelis, Susan, Quigley, Andrew, Robinson, Carol V, Young, Stephen G   +7 more
core   +2 more sources

Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

Life Science Alliance, 2021
The findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice.
Ryan von Kleeck, E. Roberts, P. Castagnino, Kyle Bruun, Sonja Brankovic, Elizabeth A. Hawthorne, Tina Xu, J. Tobias, R. Assoian   +8 more
semanticscholar   +1 more source

Inguinal herniotomy in a patient with progeria

Journal of Pediatric Surgery Case Reports, 2020
Hutchinson–Gilford progeria syndrome or progeria is a rare finding, Herein, we report a 4-year- old boy with progeria who underwent herniotomy and herniorrhaphy for left indirect inguinal hernia.
Tanvir K. Chowdhury, Afruzul Alam, Mohammad Zonaid Chowdhury, Md. Khurshid Alam Sarwar   +3 more
doaj  

Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Nature Communications, 2020
Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear.
A. J. Barinda, K. Ikeda, D. Nugroho, Donytra Arby Wardhana, Naoto Sasaki, Sakiko Honda, Ryota Urata, S. Matoba, K. Hirata, N. Emoto   +9 more
semanticscholar   +1 more source

Decreased vascular smooth muscle contractility in Hutchinson–Gilford Progeria Syndrome linked to defective smooth muscle myosin heavy chain expression

Scientific Reports, 2021
Children with Hutchinson–Gilford Progeria Syndrome (HGPS) suffer from multiple cardiovascular pathologies due to the expression of progerin, a mutant form of the nuclear envelope protein Lamin A.
Ryan von Kleeck, P. Castagnino, E. Roberts, Shefali Talwar, G. Ferrari, R. Assoian   +5 more
semanticscholar   +1 more source

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome

Nature Communications, 2020
Hutchinson-Gilford progeria syndrome is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains.
Endre Sebestyén, Fabrizia Marullo, Federica Lucini, Cristiano Petrini, Andrea Bianchi, Sara Valsoni, Ilaria Olivieri, Laura Antonelli, Francesco Gregoretti, Gennaro Oliva, Francesco Ferrari, Chiara Lanzuolo   +11 more
doaj   +1 more source

Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly because of myocardial infarction, stroke, or heart failure. The disease is
A. Sánchez-López, Carla Espinós-Estévez, Cristina González-Gómez, P. Gonzalo, M. Andrés-Manzano, Víctor Fanjul, Raquel Riquelme-Borja, Magda R. Hamczyk, Á. Macías, L. del Campo, E. Camafeita, Jesús Vázquez, A. Barkaway, Loïc Rolas, S. Nourshargh, B. Dorado, I. Benedicto, V. Andrés   +17 more
semanticscholar   +1 more source

Early Onset Diabetes in Two Children due to Progeria, a Monogenic Disease of DNA Repair

JCRPE, 2020
Progeria syndrome is a rare disorder in childhood which causes accelerated systemic aging. Due to the accelerated aging process, disorders which normally occur only in old age will appear in these children at a much younger age.
Martin Holder, Valerie Schwitzgebel
doaj   +1 more source

CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease [PDF]

, 2017
Patients with chronic kidney disease (CKD) display a progeric vascular phenotype linked to apoptosis, cellular senescence and osteogenic transformation. This has proven intractable to modelling appropriately in model organisms.
Bárány, Peter, Luttropp, Karin, McGuinness, Dagmara, Nordfors, Louise, Olauson, Hannes, Qureshi, Abdul Rashid, Ripsweden, Jonaz, Schalling, Martin, Shiels, Paul G., Stenvinkel, Peter, Söderberg, Magnus, Wennberg, Lars, Wernerson, Annika, Witasp, Anna   +13 more
core   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source