Results 121 to 130 of about 328,870 (293)

Progesterone synthesis in the nervous system: implications for myelination and myelin repair

Frontiers in Neuroscience, 2012
Progesterone is well known as a female reproductive hormone and in particular for its role in uterine receptivity, implantation and the maintenance of pregnancy. However, neuroendocrine research over the past decades has established that progesterone has
Michael eSchumacher, Rashad eHussain, Nathalie eGago, Jean-Paul eOudinet, Claudia eMattern, Abdel eGhoumari   +5 more
doaj   +1 more source

Apparition des chaleurs et de la décharge préovulatoire de LH chez la brebis de race Djallonké après synchronisation des chaleurs avec ou sans PMSG [PDF]

, 1995
En vue d'étudier l'influence de la PMSG sur l'apparition des chaleurs et le pic préovulatoire de LH chez les brebis Djallonké, les oestrus de 80 brebis cyclées ont été synchronisés à l'aide d'éponges vaginales d'acétate de fluorogestone en saison sèche ...
Kouassi, A., Meyer, Christian, Toure, Gnenekita   +2 more
core  

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Le pic de LH et l'ovulation chez les bovins. Note bibliographique [PDF]

, 2009
Le moment pour inséminer les vaches sur chaleurs naturelles est lié au moment de l'ovulation, lui-même lié au moment du pic de LH. Les chaleurs des zébus (Bos indicus) sont plus courtes que celles des taurins (Bos taurus).
Meyer, Christian, Sawadogo, Laya, Zongo, Moussa   +2 more
core  

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

PILULE ORALE OESTRO-PROGESTATIVE [PDF]

, 2012
« Un jour viendra où le principal avantage d'apprendre la médecine sera de se protéger contre les médecins ». Cette phrase de Jacques Ferron illustre bien le sentiment que certain-e-s patient-e-s cultivent à l'égard du corps médical, une confiance en les
Dall'Aglio, A.
core  

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, EarlyView.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

Effectiveness of high‐dose transvaginal progesterone supplementation for women who are undergoing a frozen‐thawed embryo transfer

Reproductive Medicine and Biology, 2018
Purpose To evaluate the effectiveness of high‐dose progesterone supplementation for women who are undergoing a frozen‐thawed embryo transfer (FET). Methods Among the 2010 FET cycles that were included in the present study, 1188 were 1200 mg/d of vaginal ...
Yihsien Enatsu, Noritoshi Enatsu, Kanako Kishi, Toshiro Iwasaki, Yukiko Matsumoto, Shoji Kokeguchi, Masahide Shiotani   +6 more
doaj   +1 more source

Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors

Progress in neurobiology, 2014
Progesterone is commonly considered as a female reproductive hormone and is well-known for its role in pregnancy. It is less well appreciated that progesterone and its metabolite allopregnanolone are also male hormones, as they are produced in both sexes
M. Schumacher, C. Mattern, A. Ghoumari, J. Oudinet, P. Liere, F. Labombarda, R. Sitruk-Ware, A. F. Nicola, R. Guennoun   +8 more
semanticscholar   +1 more source

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen, Gunjan Chauhan, Surbhi Soni, Monika Vats, Anand Kumar, Indra Bahadur   +5 more
wiley   +1 more source