Results 1 to 10 of about 516,619 (423)

Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis [PDF]

Cancer Reports
Background Progesterone rapidly induces ovarian cancer cell death through non‐genomic actions mediated by the membrane progesterone receptor (mPR). Aims We investigated the combined effects of progesterone and SN38, an active metabolite of irinotecan, on
Takahiro Koyanagi, Yasushi Saga, Yoshifumi Takahashi, Kohei Tamura, Eri Suizu, Suzuyo Takahashi, Akiyo Taneichi, Yuji Takei, Hiroaki Mizukami, Hiroyuki Fujiwara   +9 more
doaj   +2 more sources

Predictive Value of Serum Progesterone Levels on The Day of Frozen-Thawed Embryo Transfer in Determining Pregnancy Outcomes in Infertile Women: A Cohort Prospective Study [PDF]

International Journal of Fertility and Sterility
Background: Hormone replacement therapy (HRT) is the preferred protocol for endometrial preparation. Progesterone is important for successful implantation and the outcome of assisted reproductive techniques (ART).
Saeideh Dashti, Nasim Tabibnejad, Farimah Shamsi, Behnaz Gandom   +3 more
doaj   +2 more sources

Non-genomic mechanisms of progesterone action in the brain

Frontiers in Neuroscience, 2013
Progesterone is a gonadal steroid hormone whose physiological effects extend well beyond the strict confines of reproductive function. In fact, progesterone can have important effects on a variety of tissues, including the bone, the heart and the brain ...
Meharvan Singh
exaly   +3 more sources

Progesterone Synthesis in the Nervous System: Implications for Myelination and Myelin Repair

Frontiers in Neuroscience, 2012
Progesterone is well known as a female reproductive hormone and in particular for its role in uterine receptivity, implantation and the maintenance of pregnancy. However, neuroendocrine research over the past decades has established that progesterone has
Michael Schumacher, Abdel Mouman Ghoumari   +1 more
exaly   +3 more sources

Steroid Receptors and Vertebrate Evolution [PDF]

arXiv, 2019
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
Baker, Michael E.
arxiv   +2 more sources

Comparison of vaginal versus intramuscular progesterone in programmed cycles for frozen-thawed blastocyst transfer in patients with endometriosis [PDF]

Reproductive Biology and Endocrinology
Background Previous studies have shown that due to the presence of endometrium progesterone resistance in patients with endometriosis, it is considered that higher levels of progesterone may be required to achieve live birth during programmed frozen ...
Ziqi Jin, Guoxia Yang, Tianrui Wen, Benyu Miao, Chen Wang, Qingyan Zhang, Fang Gu, Yanwen Xu   +7 more
doaj   +2 more sources

Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins. [PDF]

PLoS ONE, 2014
Progesterone withdrawal is essential for parturition, but the mechanism of this pivotal hormonal change is unclear in women and other mammals that give birth without a pre-labor drop in maternal progesterone levels.
Toni N Welsh, Jonathan J Hirst, Hannah Palliser, Tamas Zakar   +3 more
doaj   +1 more source

Effect of Individualized Progesterone Supplementation for Luteal Support in Frozen-Thawed Cycles on Pregnancy Outcomes

Gynecology Obstetrics & Reproductive Medicine, 2022
Objective: In frozen-thawed embryo transfer (FET) cycles, preparing a synchronous endometrium for the embryo is essential. Aim of this study is to provide individualized luteal support in hormonally replaced FET cycles, and to evaluate mid-luteal serum ...
Gulsen Dogan Durdag, Gizem Bektas, Esengul Turkyilmaz, Halime Goktepe, Meltem Sonmezer, Yavuz Emre Sukur, Batuhan Ozmen, Cem Atabekoglu, Murat Sonmezer   +8 more
doaj   +1 more source

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Beer, Bergeron, Bertrand, Bielefeldt, Blackmore, Breit, Cahalan, Cahalan, Chandy, Clemens, Crabtree, Dolmetsch, Fiering, Foresta, Gouy, Grissmer, Grynkiewicz, Gurka, Hamill, Hess, Horn, Hunt, Karttunen, Kerschbaum, Koo, Lewis, Lewis, Lin, Logsdon, Mason, Michne, Monterroso, Negulescu, Nguyen, Pavia, Pepe, Phipps, Premack, Price, Revelli, Roussev, Runnebaum, Runnebaum, Shastri, Siiteri, Siiteri, Stites, Thastrup, Timmerman, Valera, Van Voorhis, Verheugen, Waldegger, Wu, Zweifach   +54 more
core   +3 more sources

Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses

Scientific Reports, 2020
Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood.
Katarzyna J. Siemienowicz, Yili Wang, Magda Marečková, Junko Nio-Kobayashi, Paul A. Fowler, Mick T. Rae, W. Colin Duncan   +6 more
doaj   +1 more source