Results 211 to 220 of about 219,338 (264)
Some of the next articles are maybe not open access.
The evolution of progesterone receptor ligands
Medicinal Research Reviews, 2006AbstractProgesterone is one of the first nuclear receptor hormones to be described functionally and subsequently approached as a drug target. Because progesterone (1) affects both menstruation and gestation via the progesterone receptor (PR), research aimed at modulating its activity is usually surrounded by controversy.
Shawn P. Williams +2 more
openaire +4 more sources
Progesterone antagonists and progesterone receptor modulators
Expert Opinion on Investigational Drugs, 2003Since the discovery of the antiprogestin RU 486 (mifepristone), other compounds have been synthesised that function as pure progesterone antagonists or progesterone receptor modulators. The latter are mixed agonists-antagonists. Mifepristone is usually used to terminate pregnancy but these compounds have numerous other applications in female healthcare.
openaire +3 more sources
The role of progesterone and the progesterone receptor in cancer
Expert Review of Endocrinology & Metabolism, 2017There is an abundance of accumulating data strongly suggesting there is a key role for the progesterone receptor in the molecular events effecting the growth or containment of a variety of cancers. This knowledge should lead to novel new strategies to combat various cancers, including drugs classified as progesterone receptor modulators or monoclonal ...
openaire +3 more sources
Progesterone-Progestin Receptors
1974A correlation between binding to the progestin-specific uterine cytosol receptor and with well-defined facets of progesterone action was established. Structurally similar derivatives of norprogesterone and nortestosterone were compared. Binding was measured in vitro by determining their competitive effect on the progestin-tagged uterine cytosol ...
Philibert D +2 more
openaire +3 more sources
Progesterone Receptors and Ovulation [PDF]
, 2010 The steroid hormone, progesterone, plays a critical role in the regulation of female ovulation. The physiological effects of progesterone are mediated by two nuclear receptor transcription factors, PR-A and PR-B, which are produced from a single gene and upon binding progesterone regulate the expression of specific gene networks in reproductive tissues.
openaire +2 more sources
Advances on progesterone receptor gene
Hereditas (Beijing), 2009The steroid hormone, progesterone, plays a key role in diverse events associated with female reproduction. In humans and other vertebrates, the biological activity of progesterone is mediated by modulation of the transcriptional activity of two progesterone receptors, PGR-A and PGR-B.
Wang Pq +4 more
openaire +3 more sources
Progesterone receptors in breast fibroadenomas
Journal of Steroid Biochemistry, 1979Abstract Cytosol progesterone receptors (P-R) were measured in breast fibroadenomas from 88 women, and their levels were compared to the tumor epithelial cell density and estradiol receptor levels (E-R). Three groups of fibroadenoma were distinguished: type I with a high epithelial cell density (n= 18), type III (n = 46) with low epithelial cell ...
H. Serment +3 more
openaire +3 more sources
Progesterone Receptors in Rat Thymus
Endocrinology, 1983Tritiated promegestone ([3H]R5020) is bound with high affinity in cytosol prepared from the thymus gland of both male and female rats. To prevent tracer binding to glucocorticoid receptors, we have used excess RU26988 (11 beta, 17 beta-dihydroxy-21-methyl-17 alpha-pregna-1,4,6-trien-20-yn-3-one), a highly specific synthetic glucocorticoid.
B. A. K. Khalid +2 more
openaire +3 more sources
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1989
Radiodinated and non-radiodinated 16α-iodo- and 17α-(2-iodovinyl)-19-nortestosterones are prepared and are used in progesterone receptor assays.
William Rosner +2 more
openaire +2 more sources
Radiodinated and non-radiodinated 16α-iodo- and 17α-(2-iodovinyl)-19-nortestosterones are prepared and are used in progesterone receptor assays.
William Rosner +2 more
openaire +2 more sources
Progesterone Receptor of the Human Myometrium1
The Journal of Clinical Endocrinology & Metabolism, 1975A progesterone binding protein was characterized in the cytosol of human myometrium. The receptor sedimented in the 4S region on sucrose gradients and had an equilibrium dissociation constant of 3.7 times 10-9M. Synthetic progestagens had an affinity equivalent to that of progesterone while cortisol had low affinity for the binding protein.
Doreen V. Illingworth +3 more
openaire +3 more sources