Results 211 to 220 of about 129,630 (263)

Receptors for progesterone

Gynecologic Oncology, 1974
Abstract Coordinated estrogen- and progesterone-induced changes regulate biological functions of the endometrium. The uterine deciduoma reaction is used as a model in defining the mechanism of the progesterone-induced endometrial transformations. Uterine progesterone concentrations were determined by radioimmunoassay during three critical periods ...
B R, Rao, W G, Wiest
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Progesterone and progesterone receptors in reptiles

General and Comparative Endocrinology, 2002
The role of progesterone (P) has been most extensively studied in the female reproductive tissues (ovary, reproductive tract, mammary gland) and in the brain, in which it is an important regulator and modulator in conjunction with estradiol (E). In nonmammalian vertebrate species, less work has been done on P metabolites involved in ovulation.
Noemí, Custodia-Lora, Ian P, Callard
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Novel Mechanisms of Progesterone Antagonists and Progesterone Receptor

Journal of the Society for Gynecologic Investigation, 2000
The progesterone receptor (PR), as a member of the nuclear receptor superfamily of ligand-dependent transcription factors, activates gene transcription through binding to specific palindromic progesterone response elements (PRE) in the promoter region of progestin-responsive genes.
D P, Edwards, S A, Leonhardt, E, Gass-Handel   +2 more
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Progesterone receptor and the mechanism of action of progesterone antagonists

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Currently available progesterone antagonists have been suggested to fall into two categories based on differences in how they interact with and inactivate the progesterone receptor (PR). The anti-progestin ZK98299 (Type I) impairs PR association with DNA, while Type II compounds (RU486, ZK112993, ZK98734) promote PR binding to DNA.
D P, Edwards, M, Altmann, A, DeMarzo, Y, Zhang, N L, Weigel, C A, Beck   +5 more
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Progesterone antagonists and progesterone receptor modulators

Expert Opinion on Investigational Drugs, 2003
Since the discovery of the antiprogestin RU 486 (mifepristone), other compounds have been synthesised that function as pure progesterone antagonists or progesterone receptor modulators. The latter are mixed agonists-antagonists. Mifepristone is usually used to terminate pregnancy but these compounds have numerous other applications in female healthcare.
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Phosphorylation and Progesterone Receptor Function

The Journal of Steroid Biochemistry and Molecular Biology, 1994
Four phosphorylation sites have been identified in the chicken progesterone receptor. Two of these sites exhibit basal phosphorylation which is enhanced upon treatment with hormone and two of the sites are phosphorylated in response to hormone. Mutation of one of these hormone dependent sites, Ser530 to Ala530, causes a decrease in transcriptional ...
N. L. Weigel, W. Bai, Y. Zhang, C. A. Beck, D. P. Edwards, A. Poletti   +5 more
openaire   +3 more sources

Progesterone-Progestin Receptors

1974
A correlation between binding to the progestin-specific uterine cytosol receptor and with well-defined facets of progesterone action was established. Structurally similar derivatives of norprogesterone and nortestosterone were compared. Binding was measured in vitro by determining their competitive effect on the progestin-tagged uterine cytosol ...
J P, Raynaud, D, Philibert, G, Azadian-Boulanger   +2 more
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The evolution of progesterone receptor ligands

Medicinal Research Reviews, 2006
AbstractProgesterone is one of the first nuclear receptor hormones to be described functionally and subsequently approached as a drug target. Because progesterone (1) affects both menstruation and gestation via the progesterone receptor (PR), research aimed at modulating its activity is usually surrounded by controversy.
Kevin P, Madauss, Eugene L, Stewart, Shawn P, Williams   +2 more
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Progesterone Receptors and Ovulation

2010
The steroid hormone, progesterone, plays a critical role in the regulation of female ovulation. The physiological effects of progesterone are mediated by two nuclear receptor transcription factors, PR-A and PR-B, which are produced from a single gene and upon binding progesterone regulate the expression of specific gene networks in reproductive tissues.
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Progesterone antagonists and progesterone receptor modulators: an overview

Steroids, 2003
Since the original description of the structure of the antiprogestin, mifepristone, was published, numerous related compounds have been synthesized which may function as progesterone antagonists (PAs) or progesterone receptor modulators (PRMs). The latter are mixed agonists-antagonists.
openaire   +2 more sources