Results 11 to 20 of about 68,845 (338)

Prenatal Progestin Exposure Is Associated With Autism Spectrum Disorders

Frontiers in Psychiatry, 2018
We have previously reported that prenatal progestin exposure induces autism-like behavior in offspring through ERβ (estrogen receptor β) suppression in the brain, indicating that progestin may induce autism spectrum disorders (ASD). In this study, we aim
Ling Li, Min Li, Jianping Lu, Xiaohu Ge, Weiguo Xie, Zichen Wang, Xiaoling Li, Chao Li, Xiaoyan Wang, Yan Han, Yifei Wang, Liyan Zhong, Wei Xiang, Xiaodong Huang, Haijia Chen, Paul Yao, Paul Yao, Paul Yao   +17 more
doaj   +2 more sources

DACH1 suppresses epithelial to mesenchymal transition (EMT) through Notch1 pathway and reverses progestin resistance in endometrial carcinoma

Cancer Medicine, 2019
Progestin resistance limits the effectiveness of progestin therapy in endometrial carcinoma for patients who desire to preserve fertility. To investigate the molecular mechanism of progestin resistance in endometrial carcinoma, we performed microarray ...
Qing Zhou, Wenzhi Li, Deshui Kong, Zhiming Liu, Zhengzheng Shi, Xiaohong Ma, Yongmei Li, Jie Jiang   +7 more
doaj   +2 more sources

Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation

Molecular Autism, 2018
Background Recent literatures indicate that maternal hormone exposure is a risk factor for autism spectrum disorder (ASD). We hypothesize that prenatal progestin exposure may counteract the neuroprotective effect of estrogen and contribute to ASD ...
Weiguo Xie, Xiaohu Ge, Ling Li, Athena Yao, Xiaoyan Wang, Min Li, Xiang Gong, Zhigang Chu, Zhe Lu, Xiaodong Huang, Yun Jiao, Yifei Wang, Meifang Xiao, Haijia Chen, Wei Xiang, Paul Yao   +15 more
doaj   +2 more sources

Progestin and Nuclear Progestin Receptor Are Essential for Upregulation of Metalloproteinase in Zebrafish Preovulatory Follicles

Frontiers in Endocrinology, 2018
Ovulation requires proteinases to promote the rupture of ovarian follicles. However, the identity of these proteinases remains unclear. In our previous studies using RNA-seq analysis of differential expressed genes, we found significant down-regulation ...
Dong Teng Liu, Dong Teng Liu, Nichole J. Carter, Xin Jun Wu, Wan Shu Hong, Shi Xi Chen, Yong Zhu, Yong Zhu   +7 more
doaj   +2 more sources

Nuclear Progestin Receptor (Pgr) Knockouts in Zebrafish Demonstrate Role for Pgr in Ovulation but Not in Rapid Non-Genomic Steroid Mediated Meiosis Resumption [PDF]

Frontiers in Endocrinology, 2015
Progestins, progesterone derivatives, are the most critical signaling steroid for initiating final oocyte maturation (FOM) and ovulation, in order to advance fully-grown immature oocytes to become fertilizable eggs in basal vertebrates.
Akison, Baldi, Bayaa, Boonyaratanakornkit, Chen, Conneely, Conneely, Filardo, Frye, Hagiwara, Hanna, Hanna, Hanna, Huang, Kim, Lydon, Maller, Masui, Masui, Meeker, Moenter, Prossnitz, Richards, Robker, Stormshak, Tan, Thomas, Thomas, Tian, Zhao, Zhu, Zhu   +31 more
core   +3 more sources

Weight Loss During Intrauterine Progestin Treatment for Obesity-associated Atypical Hyperplasia and Early-Stage Cancer of The Endometrium

Cancer Prevention Research, 2021
This study found that weight loss improves response rates in women with obesity and atypical hyperplasia or low-risk endometrial cancer undergoing conservative management with intrauterine progestin.
Chloe E. Barr, N. Ryan, A. Derbyshire, Y. L. Wan, M. Mackintosh, R. McVey, J. Bolton, C. Fitzgerald, Dina Awad, R. Slade, A. Syed, B. Ammori, E. Crosbie   +12 more
semanticscholar   +1 more source

Outcomes of women treated with progestin and metformin for atypical endometrial hyperplasia and early endometrial cancer: a systematic review and meta-analysis

International Journal of Gynecological Cancer, 2021
Objective Progestin therapy is the recommended fertility-sparing management of atypical endometrial hyperplasia or early-stage endometrial cancer in reproductive-aged women.
Jennifer Chae-Kim, G. Garg, L. Gavrilova-Jordan, L. Blake, Tongil Kim, Qiang Wu, C. Hayslip   +6 more
semanticscholar   +1 more source

RNA‐seq and ATAC‐seq analysis of CD163+ macrophage‐induced progestin‐insensitive endometrial cancer cells

Cancer Medicine, 2023
Background Progestins are used as fertility‐sparing regimens for young patients with stage 1A endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH).
Lulu Wang, Qiaoying Lv, Pengfei Wu, Shuhan Luo, Sijia Liu, Xiaojun Chen, Xuezhen Luo   +6 more
doaj   +1 more source

Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials

Clinical and Experimental Obstetrics & Gynecology, 2020
Background: The aim of this meta-analysis was to compare levonorgestrel intrauterine system (LNG-IUS) with oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection.
Y. Sun, X. Chen, X. Yuan, L. Xu, Y.C. Jin, T.H. Ji, X.L. Wang, H.H. Dai, W.J. Cheng   +8 more
doaj   +1 more source

Interest in Continued Use After Participation in a Study of Over-the-Counter Progestin-Only Pills in the United States

Women's Health Reports, 2022
Objective: To assess interest in continued use of over-the-counter progestin-only pills among individuals who used them in a trial. Methods: From January 2020 to September 2021, we conducted a cross-sectional online survey with individuals who completed ...
Kate Grindlay, Katherine Key, Carmela Zuniga, Alexandra Wollum, Kelly Blanchard, Daniel Grossman   +5 more
doaj   +1 more source