Results 11 to 20 of about 295,913 (316)

NR2F6 as a Prognostic Biomarker in HNSCC [PDF]

International Journal of Molecular Sciences, 2020
Head and neck squamous cell carcinoma (HNSCC)is the 6th most common cancer in humans worldwide and is associated with a poor prognosis for patients. NR2F6 has been identified as an immune checkpoint molecule in tumor-infiltrating T lymphocytes and is associated with a poor prognostic outcome in various cancers.
Luise Klapper, Julika Ribbat-Idel, Patrick Kuppler, Finn-Ole Paulsen, Karl-Ludwig Bruchhage, Dirk Rades, Anne Offermann, Jutta Kirfel, Barbara Wollenberg, Christian Idel, Sven Perner   +10 more
openaire   +2 more sources

Prognostic biomarkers of cutaneous melanoma [PDF]

Photodermatology, Photoimmunology & Photomedicine, 2022
AbstractBackground/purposeMelanomas account for only approximately 4% of diagnosed skin cancers in the United States but are responsible for the majority of deaths caused by skin cancer. Both genetic factors and ultraviolet (UV) radiation exposure play a role in the development of melanoma.
Liang, Ding, Alexandra, Gosh, Delphine J, Lee, Gabriella, Emri, Wendy J, Huss, Paul N, Bogner, Gyorgy, Paragh   +6 more
openaire   +2 more sources

Prognostic Biomarkers for Melanoma Immunotherapy [PDF]

Current Oncology Reports, 2020
Recent developments in immunotherapy have transformed the landscape of melanoma therapy. Here, we review markers for response to immunotherapy.Current immunotherapies disable immune checkpoints on T cells and other immune cells and allow immune rejection of tumor.
Twitty, Christopher G, Huppert, Laura A, Daud, Adil I   +2 more
openaire   +4 more sources

Prognostic and Predictive Biomarkers in Gliomas [PDF]

International Journal of Molecular Sciences, 2021
Gliomas are the most common central nervous system tumors. New technologies, including genetic research and advanced statistical methods, revolutionize the therapeutic approach to the patient and reveal new points of treatment options. Moreover, the 2021 World Health Organization Classification of Tumors of the Central Nervous System has fundamentally ...
Paulina Śledzińska, Marek G. Bebyn, Jacek Furtak, Janusz Kowalewski, Marzena A. Lewandowska   +4 more
openaire   +2 more sources

Prognostic biomarkers in osteoarthritis [PDF]

Current Opinion in Rheumatology, 2013
Identification of patients at risk for incident disease or disease progression in osteoarthritis remains challenging, as radiography is an insensitive reflection of molecular changes that presage cartilage and bone abnormalities. Thus there is a widely appreciated need for biochemical and imaging biomarkers.
Mukundan, Attur, Svetlana, Krasnokutsky-Samuels, Jonathan, Samuels, Steven B, Abramson   +3 more
openaire   +2 more sources

suPAR as a prognostic biomarker in sepsis [PDF]

BMC Medicine, 2012
Abstract Sepsis is the clinical syndrome derived from the host response to an infection and severe sepsis is the leading cause of death in critically ill patients. Several biomarkers have been tested for use in diagnosis and prognostication in patients with sepsis.
DONADELLO, Katia, Scolletta, Sabino, COVAJES, Cecilia, Vincent, Jean Louis   +3 more
openaire   +7 more sources

Prognostic value of miR-21 in various cancers: an updating meta-analysis. [PDF]

PLoS ONE, 2014
Recently, more and more studies investigated the value of microRNA (miRNA) as a diagnostic or prognostic biomarker in various cancers. MiR-21 was found dysregulated in almost all types of cancers.
Xin Zhou, Xiaping Wang, Zebo Huang, Jian Wang, Wei Zhu, Yongqian Shu, Ping Liu   +6 more
doaj   +1 more source

The prognostic value of biomarkers in stroke [PDF]

Immunity & Ageing, 2016
Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Matrix-Metalloproteinase-9 (MMP-9), and S100β ...
Iemolo F, Sanzaro E, Duro G, Giordano A, Paciaroni M   +4 more
openaire   +2 more sources

Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease [PDF]

, 2010
Background: Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events ...
Adam D Timmis, Kate S L McAllister, Fitzpatrick Natalie K., J. Damant (7608818), Stephen Palmer, McAllister, Kate, Aroon D Hingorani, A. D. Timmis (7608830), Hingorani, AD, Chen Ruoling, A. D. Hingorani (7602500), Damant Jacqueline, Fitzpatrick, NK, Timmis Adam D., Keith R. Abrams, J. C. Kaski (7608827), Palmer, S, Fitzpatrick, Natalie K., Chen, Ruoling, Abrams, Keith R, Harry Hemingway, Timmis, Adam D, Philipson, P, Santiago Moreno, Natalie K. Fitzpatrick, Palmer, Stephen, Turnbull, Fiona Mary, McAllister, Kate S L, Damant, J, Timmis, Adam D., K. S. L. McAllister (7608824), Moreno, Santiago, Kaski, JC, Philipson Peter, Hingorani, Aroon D, Hemingway Harry, Adam D. Timmis, Fitzpatrick, Natalie K, Abrams Keith R., Keith R. Abrams (7579436), Shipley, Martin, Palmer Stephen, Hemingway, Harry, Shipley Martin, Abrams, Keith R., Chen, R, H. Hemingway (7608809), McAllister, KSL, Shipley, M, Timmis, AD, Moreno Santiago, Natalie K Fitzpatrick, Hingorani Aroon D., Damant, Jacqueline, Juan Carlos Kaski, Fitzpatrick, Natalie, Philipson, Peter, McAllister, KS, N. K. Fitzpatrick (7608815), Kaski Juan Carlos, P. Philipson (7608812), Abrams, Keith, Kate S. L. McAllister, S. Palmer (3693193), Martin Shipley, Peter Philipson, Jacqueline Damant, M. Shipley (7608821), McAllister Kate S. L., Santiago Moreno (90184), Chen, RL, Moreno, S, Mcallister, Katherine, Abrams, KR, R. Chen (576618), Hingorani, Aroon D., Kaski, Juan Carlos, Keith R Abrams, Hemingway, H, Timmis, Adam, Aroon D. Hingorani, Ruoling Chen, Philipson, Pete, Hingorani, Aroon   +83 more
core   +1 more source

A simulation study on estimating biomarker–treatment interaction effects in randomized trials with prognostic variables

Trials, 2018
Background To individualize treatment decisions based on patient characteristics, identification of an interaction between a biomarker and treatment is necessary.
Bernhard Haller, Kurt Ulm
doaj   +1 more source