Results 71 to 80 of about 22,923,614 (357)

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

The pattern of tumor progression on first-line immune checkpoint inhibitor-based systemic therapy for Chinese advanced hepatocellular carcinoma –CLEAP 004 study

Frontiers in Immunology
BackgroundFor decades, stratification criteria for first-line clinical studies have been highly uniform. However, there is no principle or consensus for restratification after systemic treatment progression based on immune checkpoint inhibitors (ICIs ...
Chao-Xu Yang, Yang-Xun Pan, Feng Ye, Xiao-Dong Zhu, Jun Xue, Xi Li, Zhen-Gang Yuan, Lan Zhang, Li Xu, Yong-Jun Chen, Nan-Ya Wang, Hui-Chuan Sun, Xiu-Feng Liu, China Liver Cancer Study Group Young Investigators (CLEAP)   +13 more
doaj   +1 more source

Analysis of M2 macrophage-associated risk score signature in pancreatic cancer TME landscape and immunotherapy

Frontiers in Molecular Biosciences, 2023
Background: M2 macrophages perform an influential role in the progression of pancreatic cancer. This study is dedicated to explore the value of M2 macrophage-related genes in the treatment and prognosis of pancreatic cancer.Methods: RNA-Seq and clinical ...
Dashuai Yang, Fangrui Zhao, Yang Su, Yu Zhou, Jie Shen, Kailiang Zhao, Youming Ding   +6 more
doaj   +1 more source

Temporal recalibration for improving prognostic model development and risk predictions in settings where survival is improving over time

International Journal of Epidemiology, 2020
Background Prognostic models are typically developed in studies covering long time periods. However, if more recent years have seen improvements in survival, then using the full dataset may lead to out-of-date survival predictions.
Sarah Booth, R. Riley, J. Ensor, P. Lambert, M. Rutherford   +4 more
semanticscholar   +1 more source

Bone Marrow Failure as an Underrecognized Feature of KAT6A Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT KAT6A syndrome (Arboleda–Tham syndrome) is a rare disorder caused by heterozygous pathogenic variants in KAT6A, a histone acetyltransferase essential for chromatin remodeling and hematopoietic stem cell function. While neurodevelopmental features are well established, hematologic manifestations are underrecognized.
Ye Jee Shim, Bruce Crooks, Hyoung Jin Kang, Kyung Taek Hong, Jung Yoon Choi, Hye Ra Jung, Chang Ahn Seol, Rinu Mathew, Yigal Dror   +8 more
wiley   +1 more source

Programmed cell death-driven remodeling of the melanoma microenvironment enables prognostic stratification and therapeutic prediction

Frontiers in Immunology
Background and objectiveMelanoma exhibits profound biological complexity, driven by immune evasion, phenotypic plasticity, and resistance to therapy.
Bo Hu, Shengnan Chai, Xuan Li, Qiang Zhang, Mei Jin, Long Zhang   +5 more
doaj   +1 more source

Outcomes following oesophagectomy in patients with oesophageal cancer: a secondary analysis of the ICNARC Case Mix Programme Database [PDF]

, 2009
Introduction: This report describes the case mix and outcomes of patients with oesophageal cancer admitted to adult critical care units following elective oesophageal surgery in England, Wales and Northern Ireland.
Alderson, Derek, Cromwell, David A., Harrison, D. A. (David A.), Palser, Thomas R., Park, Daniel P., Perkins, Gavin D., Rowan, Katherine M., Smith, F. Gao (Fang Gao), Welch, Catherine A.   +8 more
core   +4 more sources

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Prognostic value assessment and in vitro validation of mitochondria-ferroptosis-related genes in multiple myeloma

Scientific Reports
Multiple myeloma (MM) is a malignant plasma cell tumor. Mitochondria-related genes (MRGs) are significant inducers of ferroptosis. However, research on the involvement of mitochondria-ferroptosis-related genes (MFRGs) in the MM is relatively scarce, and ...
Jing Wu, Chen Li, Jiayou Zhang, Jing Su, Yuting Xiao, Linhua Ji   +5 more
doaj   +1 more source

Decoding the hypoxic tumor microenvironment in colorectal cancer for prognostic modeling and therapeutic target discovery

Frontiers in Immunology
BackgroundHypoxia is a hallmark of the colorectal cancer (CRC) tumor microenvironment (TME) that drives malignant progression, chemoresistance, and immune evasion.
Xiao-Cui Duan, Yan Zhou, Fan Feng, Hai-Bo Jiang, Mei-Lin Wang, Zhe Han, Hong-Fei Pang, Yu-Hang Liu, Heng-Zhe Jia, Meng- He, Hong-Pan Xu, Yuan-Yuan Wang   +11 more
doaj   +1 more source