Results 161 to 170 of about 595 (184)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

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Protein expression of programmed cell death ligand 1 and ligand 2 and their prognostic values in extensive-stage small cell lung cancer.

Journal of Clinical Oncology, 2021
e20593 Background: The receptor-ligand interaction between programmed cell death protein-1 (PD-1) and its ligands (PD-L1 and PD-L2) plays a critical role in tumor immune evasion and has become a therapeutic target in a number of cancer types, including extensive stage small cell lung cancer (ES-SCLC).
Ke (Kirsten) Zu, Jeanette Bæhr Georgsen, Peter Meldgaard, Anne Deitz, Mark Ayers, Maria Catherine Pietanza, Torben Steiniche   +6 more
openaire   +1 more source

Serum levels of soluble programmed cell death protein 1 and soluble programmed cell death protein ligand 2 are increased in systemic lupus erythematosus and associated with the disease activity

Lupus, 2020
Objective Programmed cell death protein 1 (PD-1) pathway plays important roles in systemic lupus erythematosus (SLE). We aimed to elucidate the association of serum soluble PD-1 (sPD-1) and related molecules with SLE and to explore their usefulness as biomarkers.
Shinya Hirahara, Yasuhiro Katsumata, Hidenaga Kawasumi, Yashushi Kawaguchi, Masayoshi Harigai   +4 more
openaire   +2 more sources

LUP916517 Supplemental Material - Supplemental material for Serum levels of soluble programmed cell death protein 1 and soluble programmed cell death protein ligand 2 are increased in systemic lupus erythematosus and associated with the disease activity

2020
Supplemental material, LUP916517 Supplemental Material for Serum levels of soluble programmed cell death protein 1 and soluble programmed cell death protein ligand 2 are increased in systemic lupus erythematosus and associated with the disease activity by Shinya Hirahara, Yasuhiro Katsumata, Hidenaga Kawasumi, Yashushi Kawaguchi and Masayoshi Harigai ...
Hirahara, Shinya, Katsumata, Yasuhiro, Hidenaga Kawasumi, Yashushi Kawaguchi, Harigai, Masayoshi   +4 more
openaire   +1 more source

The Roles of Programmed Cell Death Ligand-1/ Programmed Cell Death-1 (PD-L1/PD-1) in HPV-induced Cervical Cancer and Potential for their Use in Blockade Therapy

Current Medicinal Chemistry, 2021
Xiangyang Xue, Kong-Nan Zhao, Lifang Zhang   +2 more
exaly  

Differential Immune-Related Microenvironment Determines Programmed Cell Death Protein-1/Programmed Death-Ligand 1 Blockade Efficacy in Patients With Advanced NSCLC

Journal of Thoracic Oncology, 2021
Noriko Motoi, Hidehito Horinouchi, Masayuki Shirasawa   +2 more
exaly  

Differential expression of programmed death-1 and its ligand, programmed death ligand-1 in oral squamous cell carcinoma with and without oral submucous fibrosis

Archives of Oral Biology, 2020
Liangjuan Fang, Hongzhi Quan, Yanjia Hu   +2 more
exaly  

Incidence of Pneumonitis With Use of Programmed Death 1 and Programmed Death-Ligand 1 Inhibitors in Non-Small Cell Lung Cancer

Chest, 2017
Mónica Khunger, Nathan Pennell, Adrian V Hernández   +2 more
exaly  

Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes

European Journal of Cancer, 2014
Yih-Leong Chang, Ching-Yao Yang, Pan-Chyr Yang   +2 more
exaly  

Clinicopathological analysis of programmed cell death 1 and programmed cell death ligand 1 expression in the tumour microenvironments of diffuse large B cell lymphomas

Histopathology, 2016
Dae Seog Heo, Tae Min Kim, Yoon Kyung Jeon   +2 more
exaly