Results 81 to 90 of about 181,344 (173)

VRK2 targeting potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma through MYC destabilization

Nature Communications
Dysregulation of MYC proto-oncogene, bHLH transcription factor (MYC) represents a common yet mechanistically unresolved driver of hepatocellular carcinoma (HCC).
Chen Su, Zhibin Liao, Jie Mo, Furong Liu, Weijian Wang, Haoquan Zhang, Hongwei Zhang, Yachong Liu, Yonglong Pan, He Zhu, Xiaoping Chen, Zhanguo Zhang, Peng Zhu, Bixiang Zhang   +13 more
doaj   +1 more source

Applications and challenges of immunotherapy in the management of gastric adenocarcinoma: current status and future perspectives

World Journal of Surgical Oncology
Gastric adenocarcinoma (GAC) remains a significant global public health challenge, characterized by high incidence and mortality rates. Progress in tumor immunology has introduced immune checkpoint inhibitors (ICIs) targeting the programmed cell death-1 (
Zhiyao Chen, Yunbin Ma, Jianan Chen
doaj   +1 more source

Neoadjuvant anlotinib/sintilimab plus chemotherapy in triple-negative breast cancer (NeoSACT): Phase 2 trial

Cell Reports Medicine
Summary: Tumor angiogenesis contributes to immune evasion, and vascular normalization enhances immunotherapy response by reshaping the tumor microenvironment.
Liulu Zhang, Lu Yang, Yan Ge, Zhaowen Zhu, Bo Chen, Ciqiu Yang, Hongfei Gao, Mei Yang, Teng Zhu, Kun Wang   +9 more
doaj   +1 more source

Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions [v1; ref status: indexed, http://f1000r.es/5ga]

F1000Research, 2015
Diphencyprone (DPCP) is a hapten that causes delayed-type hypersensitivity (DTH) reactions in human skin, and is used as a topical therapeutic for alopecia areata, warts, and cutaneous melanoma metastases.  We examined peak DTH reactions induced by DPCP (
Nicholas Gulati, Mayte Suárez-Fariñas, Joel Correa da Rosa, James G. Krueger   +3 more
doaj   +1 more source

mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer

Journal for ImmunoTherapy of Cancer
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is highly transmissible and evades pre-established immunity.
Dan H Barouch, Yi Wang, Mark P Rubinstein, Zihai Li, Anqi Li, Sarah Reisinger, Peter G Shields, Qin Ma, No-Joon Song, Dongjun Chung, Karthik B Chakravarthy, Chelsea Bolyard, Hyeongseon Jeon, Kelsi Reynolds, Kevin P Weller, Sizun Jiang, Eugene M Oltz   +16 more
doaj   +1 more source

Effect of Insulin-Like Growth Factor-1 (IGF-1) on the expression of NFκB and cFLIP in Bovine Granulosa Cells [PDF]

, 2014
Infertility, often attributed to follicular atresia, is a growing problem in the agricultural industry. Programmed cell death, also known as apoptosis, is a contributing factor of follicular atresia.
Docos, Samantha Kathleen
core   +1 more source

Nivolumab plus ipilimumab in the treatment of advanced melanoma. [PDF]

, 2015
Advanced melanoma has historically been a difficult disease to treat due to few effective systemic treatment options. However, over the past few years, scientific advancements in immune checkpoint inhibition have resulted in several novel approaches that
Daud, Adil I, Tsai, Katy K
core   +1 more source

Bioactive Compounds From Torbangun [Plectranthus Amboinicus (Lour.) Spreng] Chloroform Fraction Induce Apoptosis in Breast Cancer (Mcf-7 Cells) in Vitro [PDF]

, 2017
Torbangun (Plectranthus amboinicus (Lour.) Spreng) is a medicinal plant that has been traditionally used in tropical countries to cure various illnesses.
Andarwulan, N. (Nuri), Giriwono, P. E. (Puspo), Pamungkas, J. (Joko), Yulianto, W. (Wahid)   +3 more
core  

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

167 Increased programmed cell death 1 ligand 2 (PD-L2) protein and transcript levels in triple negative breast cancer patients improve prognostic value through immune pathway activation

Regular and Young Investigator Award Abstracts, 2023
Joe Yeong, Bernett Lee, Jabed Iqbal, Dong Yeul Lee, Clara Ong, Stefano Perna, Puay Tan   +6 more
openaire   +2 more sources