Results 261 to 270 of about 287,893 (307)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Longitudinal Immune Profiling of T Cell Exhaustion During IL-17A Blockade in a Patient With HLA-B27-negative Spondyloarthritis and Sjögren's Syndrome: A Case Report. [PDF]

In Vivo
Su YS, Lu JW, Ho YJ, Lui SW, Hsieh TY, Jheng WL, Liu FC.   +6 more
europepmc   +1 more source

Enhanced efficacy of dual chimeric antigen receptor-T cells targeting programmed death-ligand 1 and cancer-associated fibroblasts in colorectal cancer in vitro

Yang Gao, Chunxiong Luo, Hua Yang, Qin Xie, Han He, Jiawei Li, Jidong Miao   +6 more
openalex   +1 more source

Triazine‐Trione Thermosets with High Processability for Scaffold Applications in Bone Tissue Engineering

Advanced Healthcare Materials, EarlyView.
Novel photo‐clickable triazine‐trione thermosets can be shaped and cured under mild conditions, including room and physiological temperatures. These materials are biocompatible and support osteogenic differentiation of bone marrow–derived mesenchymal stem cells on their surface.
Åshild Johansen, Shuntaro Yamada, Daniel J. Hutchinson, Mohammed A. Yassin, Samih Mohamed‐Ahmed, Cecilie Gjerde, Michael Malkoch, Kamal Mustafa   +7 more
wiley   +1 more source

Functional Characterization of Rice Spotted-Leaf Mutant <i>HM113</i> Reveals an Amino Acid Substitution in a Cysteine-Rich Receptor-like Kinase. [PDF]

Plants (Basel)
Sanglou RK, Kampire MG, Xu X, Wu JL, Gong J, Zhang X.   +5 more
europepmc   +1 more source

Programmed cell death receptor 1 inhibitor Pembrolizumab in the treatment of advanced gastric cancer

Xuemei Yi, Hong-Qiao Cai, Yan Jiao
openalex   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma. [PDF]

J Immunother Cancer
Herold N, Bochem J, Leyens J, Wingerter S, Forchhammer S, Spreuer J, Deseke M, Yurttas C, Nocerino P, Antunes Dos Reis R, Amaral T, Wagner NB, Thiel K, Soffel D, Bieber K, Terheyden P, Wesch D, Oberg HH, Sebens S, Claassen M, Königsrainer A, Garbe C, Pawelec G, Meier F, Löffler MW, Weide B, Prinz I, Ravens S, Kordasti S, Eigentler T, Wistuba-Hamprecht K.   +30 more
europepmc   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source