Results 201 to 210 of about 2,386,530 (346)

Comparison of programmed death-1 (PD-1)-positive T-cells with known prognostic indicators in breast cancer. [PDF]

J Family Med Prim Care
Kaushik A, Jaiswal A, Priya B, Jain A, Sharma S.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The co-delivery of Programmed Death 1 ligands enhances and prolongs rAAV-mediated gene expression in pre-immunized mice. [PDF]

Gene Ther
Käyhty P, Nieminen T, Eriksson RAE, Tumelius R, Tawfek A, Laidinen S, Ruotsalainen AK, Bailey A, Galibert L, Lesch HP, Ylä-Herttuala S, Airenne KJ.   +11 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Expression of Programmed Death-1 Ligands (PD-L1 and PD-L2) in Endometrial Carcinoma: Immunohistochemical Study. [PDF]

Asian Pac J Cancer Prev
Shibel PE, Mamdouh RR, Salama ME, Mahmoud SA.   +3 more
europepmc   +1 more source

Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors? [PDF]

, 2015

core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Efficacy and safety of programmed death-1 inhibitors combined with chemotherapy in patients with advanced gastric cancer. [PDF]

BMC Gastroenterol
Cheng X, Zhang Y, Li X, Xu Z, Chen Y.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Combination of racotumomab immunotherapy with programmed death-1 blockade in a preclinical model of non-small cell lung cancer. [PDF]

Transl Lung Cancer Res
Segatori VI, Rojo S, Gulino CA, Capobianco CS, Ferreira GM, Crispo M, Demarco IA, Spitzer E, Gabri MR, Alonso DF.   +9 more
europepmc   +1 more source