Results 71 to 80 of about 107,466 (266)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Metaverse-integrated programming education model with student-student and student-AI pairing

Educational Technology & Society
Metaverse and pair programming are effective approaches that can be used in programming education. Combining these methods could potentially enhance both the learning experience and outcomes; however, research on their integration is currently extremely ...
Najihah Binti Nasir, Shivani Devi and Seong Baeg Kim
doaj   +1 more source

Learners’ views about cloud computing-based group activities

SHS Web of Conferences, 2017
Thanks to its use independently of time and place during the process of software development and by making it easier to access to information with mobile technologies, cloud based environments attracted the attention of education world and this ...
Yildirim Serkan, Bölen Mehmet Cem, Yildirim Gürkan   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

An experimental study of structured generative AI integration to mitigate pedagogical, cognitive, and ethical barriers in programming education

Frontiers in Computer Science
Generative artificial intelligence (GenAI) is used in programming education; however, its adoption can introduce pedagogical misalignment, shallow cognitive engagement, and ethical risks that threaten the sustenance of programming skills of students ...
Jemimah Nathaniel, Jemimah Nathaniel, Solomon Sunday Oyelere, Jarkko Suhonen, Matti Tedre   +4 more
doaj   +1 more source

Students' Learning Behaviour in Programming Education Analysis: Insights from Entropy and Community Detection. [PDF]

Entropy (Basel), 2023
Mai TT, Crane M, Bezbradica M.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Pedagogical Transformation and Teaching Practice in Programming Education Through AI Coding Assistants: Faculty Perspectives and the AI Coding Assistant Adoption Framework

Applied Sciences
The rapid integration of artificial intelligence (AI) into higher education is reshaping teaching, learning, and assessment, particularly in programming education.
Manal Alanazi, Alice Li, Ahlam Almalawi, Halima Samra, Ben Soh   +4 more
doaj   +1 more source

How problem difficulty and order influence programming education outcomes in online judge systems. [PDF]

Heliyon, 2023
Wang J, Lin P, Tang Z, Chen S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source