Results 11 to 20 of about 17,221 (177)

JC virus-DNA detection is associated with CD8 fffector accumulation in peripheral blood of patients with multiple sclerosis under natalizumab treatment, independently from JC virus serostatus [PDF]

, 2018
Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus ...
Anzivino, Elena, Ciardi, Maria R., Cortese, Antonio, D’Abramo, Alessandra, Francia, Ada, Frontoni, Marco, Iannetta, Marco, Lichtner, Miriam, Mastroianni, Claudio M., Morreale, Manuela, Oliva, Alessandra, Pietropaolo, Valeria, Pontecorvo, Simona, Prezioso, Carla, Rodio, Donatella Maria, Vullo, Vincenzo, Zingaropoli, Maria A.   +16 more
core   +3 more sources

Virus demyelination [PDF]

, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC ...
Fazakerley, John K, Walker, Robert
core   +1 more source

Treatment of progressive multifocal leukoencephalopathy [PDF]

Journal of Neurology, 2019
Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive demyelinating disease of the central nervous system caused by John Cunningham polyomavirus (JCV), a globally seroprevelant virus that commonly causes a silent or benign infection. However, in immunocompromised patients JCV can be reactivated. In this situation, most organs remain
Castle, Daniel, Robertson, Neil P.
openaire   +3 more sources

Immunological biomarkers identifying natalizumab-treated multiple sclerosis patients at risk of progressive multifocal leukoencephalopathy [PDF]

, 2014
Natalizumab-induced progressive multifocal leukoencephalopathy (PML) appears to be unleashed by complex interactions between viral and immunological host factors leading the latent form of JC virus to become pathogenic.
A.SOTTINI, D.BERTOLI, F.SERANA, L.CAIMI, L.IMBERTI, M. VAGLIO TESSITORE, M.CHIARINI, R.CAPRA, V.GIUSTINI   +8 more
core   +1 more source

Immunology of progressive multifocal leukoencephalopathy [PDF]

Journal of NeuroVirology, 2015
The high prevalence of asymptomatic JC polyomavirus (JCV) infection in the general population indicates coexistence with the human host and efficient immune control in healthy individuals. For unknown reasons, kidney-resident archetypic JCV strains can turn into neurotropic JCV strains which in hereditary or acquired states of immunodeficiency cause ...
Jelcic, Ivan, Jelcic, Ilijas, Faigle, Wolfgang, Sospedra, Mireia, Martin, Roland   +4 more
openaire   +4 more sources

Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report [PDF]

, 2010
Background To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir. Case Presentation A 35-year-old immunocompetent man who developed progressive hemianopsia, aphasia, and limb weakness underwent repeated MRI ...
Halvor Naess, Solveig Glad, Anette Storstein, Christine H Rinaldo, Sverre J Mørk, Kjell-Morten Myhr, Hans Hirsch, N Khanna, L Kappos, KR Carson, KR Carson, JR Berger, A De Luca, JF Viallard, JF Viallard, MT Roberts, CM Marra, K Tan, H Linda, CB Drachenberg, A Egli, RW Price, P Cinque, G Meintjes, A Langer-Gould, RL Cardenas, J Berenguer   +26 more
core   +1 more source

Frequent Infection of Cerebellar Granule Cell Neurons by Polyomavirus JC in Progressive Multifocal Leukoencephalopathy [PDF]

, 2009
Progressive multifocal leukoencephalopathy (PML) occurs most often in immunosuppressed individuals. The lesions of PML result from astrocyte and oligodendrocyte infection by the polyomavirus JC (JCV); JCV has also been shown to infect and destroy ...
Beckwith, Curt, Bell, Jeanne E., Cheng, Yi Min, Joseph, Jeffrey T., Kesari, Santosh, Koralnik, Igor J., Stopa, Edward, Wuethrich, Christian   +7 more
core   +1 more source

The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]

, 2017
Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna, Ibba, Gabriele, Palamara, Anna T., Pietropaolo, Valeria, White, Martyn K., Wollebo, Hassen, Wollebo|   +6 more
core   +1 more source

Comparison of real-time PCR and hemagglutination assay for quantitation of human polyomavirus JC [PDF]

, 2006
Human polyomavirus JC (JCV), the etiological agent of the disease progressive multifocal leukoencephalopathy (PML) affects immunocompromised patients particularly patients with AIDS. In vitro studies of JCV infection are hampered by the lack of sensitive
Nerurkar Vivek R, Verma Saguna, Bui Thomas, Nguyen Taylor, Chapagain Moti L   +4 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source