Results 21 to 30 of about 10,287 (171)

PARP-1 deregulation in multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Background Poly (ADP-ribose) polymerase 1 (PARP-1) plays pivotal roles in immune and inflammatory responses. Accumulating evidence suggests PARP-1 as a promising target for immunomodulation in multiple sclerosis and natalizumab-associated progressive ...
Maria Meira, Claudia Sievers, Francine Hoffmann, Heidi Bodmer, Tobias Derfuss, Jens Kuhle, Aiden Haghikia, Ludwig Kappos, Raija LP Lindberg   +8 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy triggered by COVID-19 in a previously asymptomatic person living with undiagnosed HIV infection

International Journal of Infectious Diseases, 2023
This report presents the case of a 47-year-old male patient who worked as a mathematics teacher and experienced the sudden onset of disorientation, aphasia, and acalculia during an online class.
Yago Marcos Pessoa-Gonçalves, Thaís Soares Farnesi-de-Assunção, Marlos Aureliano Dias de Sousa, Luis Marcos Ferreira, Junior, Beatriz Sodré Matos, Anna Victória Bernardes Borges, Ana Carolina de Morais Oliveira-Scussel, Alex Eduardo da Silva, Carlo José Freire Oliveira, Marcos Vinicius da Silva, Virmondes Rodrigues, Junior   +10 more
doaj   +1 more source

Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab

Emerging Infectious Diseases, 2018
Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore ...
Martin Martinot, Guido Ahle, Inesa Petrosyan, Camille Martinez, Dragos M. Gorun, Mahsa Mohseni-Zadeh, Samira Fafi-Kremer, Martine Tebacher-Alt   +7 more
doaj   +1 more source

Acquired immunodeficiency syndrome-related progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome: prevalence, main characteristics, and outcomes in a Brazilian center

Arquivos de Neuro-Psiquiatria, 2023
Background Progressive multifocal leukoencephalopathy (PML) - immune reconstitution inflammatory syndrome (IRIS) in people living with HIV/AIDS (PLWHA) has been rarely described in low- and middle-income countries.
Monize Nascimento Santana, Raphaela Ferrari, Arthur Cassa Macedo, Rosa Maria Nascimento Marcusso, Ruan de Andrade Fernandes, José Ernesto Vidal   +5 more
doaj   +1 more source

Treatment of progressive multifocal leukoencephalopathy [PDF]

Journal of Neurology, 2019
Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive demyelinating disease of the central nervous system caused by John Cunningham polyomavirus (JCV), a globally seroprevelant virus that commonly causes a silent or benign infection. However, in immunocompromised patients JCV can be reactivated. In this situation, most organs remain
Castle, Daniel, Robertson, Neil P.
openaire   +3 more sources

Progressive multifocal leukoencephalopathy: new concepts

Arquivos de Neuro-Psiquiatria, 2013
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression.
Marco A. Lima
doaj   +1 more source

Progressive multifocal leukoencephalopathy: rheumatological aspects

Современная ревматология, 2015
Progressive multifocal leukoencephalopathy (PML) is a severe progressive viral disease that affects the central nervous system in patients with immunodeficiency.
Boris Sergeevich Belov
doaj   +1 more source

Smoldering myeloma presenting as progressive multifocal leukoencephalopathy: a case report

Journal of Medical Case Reports, 2012
Introduction Progressive multifocal leukoencephalopathy is an opportunistic infection occurring in patients with severe cellular immunodeficiency. This case highlights the role of cellular immunodeficiency in the reactivation of John Cunningham virus in ...
Troppmann Martina, Büttner Roland, Böwer Michael, Salzberger Bernd   +3 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy treated with interleukin-7

Clinical Infection in Practice, 2020
Background: Progressive multifocal leukoencephalopathy (PML) is a rare devastating brain infection caused by the JC polyomavirus (JCPyV) in patients with impaired cellular immune responses. In the absence of effective anti-viral therapy, it is unclear if
Karl B. Alstadhaug, Christine Hanssen Rinaldo, Liv Osnes, Irini Sereti, Hilde K. Ofte   +4 more
doaj   +1 more source

Immunology of progressive multifocal leukoencephalopathy [PDF]

Journal of NeuroVirology, 2015
The high prevalence of asymptomatic JC polyomavirus (JCV) infection in the general population indicates coexistence with the human host and efficient immune control in healthy individuals. For unknown reasons, kidney-resident archetypic JCV strains can turn into neurotropic JCV strains which in hereditary or acquired states of immunodeficiency cause ...
Jelcic, Ivan, Jelcic, Ilijas, Faigle, Wolfgang, Sospedra, Mireia, Martin, Roland   +4 more
openaire   +4 more sources