Results 21 to 30 of about 82,833 (333)

Progressive Multifocal Leukoencephalopathy in a Patient With Progressive Multiple Sclerosis Treated With Ocrelizumab Monotherapy.

JAMA Neurology, 2021
Importance Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection caused by the JC virus that has no proven effective treatment.
Arpan Patel, J. Sul, M. Gordon, J. Steinklein, Shayna Y. Sanguinetti, B. Pramanik, D. Purohit, V. Haroutunian, Alex K. Williamson, I. Koralnik, Asaff Harel   +10 more
semanticscholar   +1 more source

Further expansion and confirmation of phenotype in rare loss of YWHAE gene distinct from Miller–Dieker syndrome

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 526-539, February 2023., 2023
Abstract Deletion of 17p13.3 has varying degrees of severity on brain development based on precise location and size of the deletion. The most severe phenotype is Miller–Dieker syndrome (MDS) which is characterized by lissencephaly, dysmorphic facial features, growth failure, developmental disability, and often early death.
Elizabeth K. Baker, Casey J. Brewer, Leonardo Ferreira, Mark Schapiro, Jeffrey Tenney, Heather M. Wied, Beth M. Kline‐Fath, Teresa A. Smolarek, K. Nicole Weaver, Robert J. Hopkin   +9 more
wiley   +1 more source

Adoptive Transfer of JC Virus‐Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy

Annals of Neurology, 2021
Progressive multifocal leukoencephalopathy (PML) is still burdened by high mortality in a subset of patients, such as those affected by hematological malignancies.
G. Berzero, S. Basso, L. Stoppini, Andrea Palermo, A. Pichiecchio, M. Paoletti, Federica Lucev, S. Gerevini, A. Rossi, E. Vegezzi, L. Diamanti, P. Bini, M. Gastaldi, S. Delbue, C. Perotti, E. Seminari, M. Faraci, M. Luppi, F. Baldanti, M. Zecca, E. Marchioni, P. Comoli   +21 more
semanticscholar   +1 more source

Real‐world application of plasmapheresis for neurological disease: Results from the Japan‐Plasmapheresis Outcome and Practice Patterns Study

Therapeutic Apheresis and Dialysis, Volume 27, Issue 1, Page 123-135, February 2023., 2023
Abstract Introduction Plasmapheresis is a well‐recognized treatment for autoimmune neurological diseases in Japan. However, the practice varies depending on the facility, and the actual treatment conditions are unclear. Methods To clarify real‐world conditions, a prospective observational study was conducted on patients with neurological diseases who ...
Youwei Lin, Satoru Oji, Katsuichi Miyamoto, Tomoko Narita, Mana Kameyama, Hidenori Matsuo   +5 more
wiley   +1 more source

Advances in Treatment of Progressive Multifocal Leukoencephalopathy

Annals of Neurology, 2021
Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV), which occurs in immunocompromised individuals. Management of PML relies on restoration of immunity within the CNS.
R. Bernard-Valnet, I. Koralnik, R. D. Du Pasquier   +2 more
semanticscholar   +1 more source

MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation

American Journal of Neuroradiology, 2021
BACKGROUND AND PURPOSE: There are no validated imaging criteria for the diagnosis of progressive multifocal leukoencephalopathy in the cerebellum. Here we introduce the MR imaging shrimp sign, a cerebellar white matter lesion identifiable in patients ...
N. Adra, A.E. Goodheart, O. Rapalino, P. Caruso, S. Mukerji, R. González, N. Venna, J. Schmahmann   +7 more
semanticscholar   +1 more source

Risk of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patient Treated With Natalizumab: A Systematic Review

Cureus, 2021
Natalizumab, a monoclonal antibody acting on alpha4 integrin receptors, is frequently used to treat multiple sclerosis patients. The biggest downside is the risk of development of progressive multifocal leukoencephalopathy, an immune-related condition ...
G. Vivekanandan, Ansha P Abubacker, Revathi Myneni, Harshika Chawla, A. Iqbal, Amit S Grewal, Andrew Ndakotsu, Safeera Khan   +7 more
semanticscholar   +1 more source

Progressive multifocal leukoencephalopathy in a patient with novel mutation in the RAC2 gene: a case report

Journal of Medical Case Reports, 2022
Background Progressive multifocal leukoencephalopathy is a rare demyelinating disease that is often secondary to lytic destruction of oligodendrocytes and, to a lesser extent, to astrocytes’ response to human neurotrophic John Cunningham polyomavirus ...
Sima Bahrami, Saba Arshi, Mohammad Nabavi, Mohammad Hassan Bemanian, Morteza Fallahpour, Afshin Rezaeifar, Sima Shokri   +6 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease

Nature Reviews Neurology, 2020
Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic infection in the general population. Emerging evidence that PML can be ameliorated
I. Cortese, D. Reich, A. Nath
semanticscholar   +1 more source

A case of progressive multifocal leukoencephalopathy in a post-kidney transplant patient with improvement after discontinuation of immunosuppressive drugs and combination therapy with mefloquine and mirtazapine

Renal Replacement Therapy, 2023
Background Progressive multifocal leukoencephalopathy is a rare disease, but the prognosis is very poor, especially in the immunosuppressed state with a non-HIV background, and there is no established treatment.
Neri Sone, Hiroki Nishiwaki, Mayu Shimokawa, Keishu Kawanishi, Tsuyoshi Oshiro, Reiji Takami, Natsuki Taira, Masahito Amagasa, Shinya Omiya, Tadahide Maezumi, Yoko Nabeshima, Kazuo Nakamichi, Yoshiharu Miura, Fumihiko Koiwa   +13 more
doaj   +1 more source