Results 31 to 40 of about 20,462 (241)

JC virus-DNA detection is associated with CD8 fffector accumulation in peripheral blood of patients with multiple sclerosis under natalizumab treatment, independently from JC virus serostatus [PDF]

, 2018
Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus ...
Anzivino, Elena, Ciardi, Maria R., Cortese, Antonio, D’Abramo, Alessandra, Francia, Ada, Frontoni, Marco, Iannetta, Marco, Lichtner, Miriam, Mastroianni, Claudio M., Morreale, Manuela, Oliva, Alessandra, Pietropaolo, Valeria, Pontecorvo, Simona, Prezioso, Carla, Rodio, Donatella Maria, Vullo, Vincenzo, Zingaropoli, Maria A.   +16 more
core   +3 more sources

The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]

, 2017
Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna, Ibba, Gabriele, Palamara, Anna T., Pietropaolo, Valeria, White, Martyn K., Wollebo, Hassen, Wollebo|   +6 more
core   +1 more source

Progressive multifocal leukoencephalopathy: new concepts

Arquivos de Neuro-Psiquiatria, 2013
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression.
Marco A. Lima
doaj   +1 more source

Immunological biomarkers identifying natalizumab-treated multiple sclerosis patients at risk of progressive multifocal leukoencephalopathy [PDF]

, 2014
Natalizumab-induced progressive multifocal leukoencephalopathy (PML) appears to be unleashed by complex interactions between viral and immunological host factors leading the latent form of JC virus to become pathogenic.
A.SOTTINI, D.BERTOLI, F.SERANA, L.CAIMI, L.IMBERTI, M. VAGLIO TESSITORE, M.CHIARINI, R.CAPRA, V.GIUSTINI   +8 more
core   +1 more source

Progressive multifocal leukoencephalopathy: rheumatological aspects

Современная ревматология, 2015
Progressive multifocal leukoencephalopathy (PML) is a severe progressive viral disease that affects the central nervous system in patients with immunodeficiency.
Boris Sergeevich Belov
doaj   +1 more source

Progressive multifocal leukoencephalopathy treated with interleukin-7

Clinical Infection in Practice, 2020
Background: Progressive multifocal leukoencephalopathy (PML) is a rare devastating brain infection caused by the JC polyomavirus (JCPyV) in patients with impaired cellular immune responses. In the absence of effective anti-viral therapy, it is unclear if
Karl B. Alstadhaug, Christine Hanssen Rinaldo, Liv Osnes, Irini Sereti, Hilde K. Ofte   +4 more
doaj   +1 more source

Smoldering myeloma presenting as progressive multifocal leukoencephalopathy: a case report

Journal of Medical Case Reports, 2012
Introduction Progressive multifocal leukoencephalopathy is an opportunistic infection occurring in patients with severe cellular immunodeficiency. This case highlights the role of cellular immunodeficiency in the reactivation of John Cunningham virus in ...
Troppmann Martina, Büttner Roland, Böwer Michael, Salzberger Bernd   +3 more
doaj   +1 more source

Frequent Infection of Cerebellar Granule Cell Neurons by Polyomavirus JC in Progressive Multifocal Leukoencephalopathy [PDF]

, 2009
Progressive multifocal leukoencephalopathy (PML) occurs most often in immunosuppressed individuals. The lesions of PML result from astrocyte and oligodendrocyte infection by the polyomavirus JC (JCV); JCV has also been shown to infect and destroy ...
Beckwith, Curt, Bell, Jeanne E., Cheng, Yi Min, Joseph, Jeffrey T., Kesari, Santosh, Koralnik, Igor J., Stopa, Edward, Wuethrich, Christian   +7 more
core   +1 more source

Brainstem progressive multifocal leukoencephalopathy

European Journal of Neurology, 2020
AbstractBackground and purposeProgressive multifocal leukoencephalopathy (PML) is a severe infection caused by the polyomavirus JC that develops in the central nervous system (CNS) of immunosuppressed patients. The infection frequently starts in the brain hemispheres and can spread into other CNS regions such as the brainstem.
Gautier Breville, Igor J. Koralnik, Patrice H. Lalive   +2 more
openaire   +3 more sources

The Modern Value of Clinical Autopsies

Acta Médica Portuguesa, 2015
Keywords: Autopsy; Antiretroviral Therapy, Highly Active; HIV Infections; Leukoencephalopathy, Progressive Multifocal.
Carlos Marques Pontinha
doaj   +1 more source