Results 41 to 50 of about 82,833 (333)

Acquired immunodeficiency syndrome-related progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome: prevalence, main characteristics, and outcomes in a Brazilian center

Arquivos de Neuro-Psiquiatria, 2023
Background Progressive multifocal leukoencephalopathy (PML) - immune reconstitution inflammatory syndrome (IRIS) in people living with HIV/AIDS (PLWHA) has been rarely described in low- and middle-income countries.
Monize Nascimento Santana, Raphaela Ferrari, Arthur Cassa Macedo, Rosa Maria Nascimento Marcusso, Ruan de Andrade Fernandes, José Ernesto Vidal   +5 more
doaj   +1 more source

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy [PDF]

, 2006
Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients.
Barkhof, F., Clifford, D.B., Curfman, B., Fahle, G., Fischer, S., Habil, M., Hou, J., Jäger, H.R., Major, E.O., Miszkiel, K., Mueller-Lenke, N., Radue, E.-W., Ryschkewitsch, C., Sanchez, E., Yousry, T.A.   +14 more
core   +1 more source

Immunology of progressive multifocal leukoencephalopathy [PDF]

Journal of NeuroVirology, 2015
The high prevalence of asymptomatic JC polyomavirus (JCV) infection in the general population indicates coexistence with the human host and efficient immune control in healthy individuals. For unknown reasons, kidney-resident archetypic JCV strains can turn into neurotropic JCV strains which in hereditary or acquired states of immunodeficiency cause ...
Jelcic, Ivan, Jelcic, Ilijas, Faigle, Wolfgang, Sospedra, Mireia, Martin, Roland   +4 more
openaire   +5 more sources

EFFICIENT PROPAGATION OF ARCHETYPE JC POLYOMAVIRUS IN COS-7 CELLS: EVALUATION OF REARRANGEMENTS WITHIN NCCR STRUCTURAL ORGANIZATION DURING TRANSFECTION. [PDF]

, 2017
John Cunningham virus (JCPyV) is an ubiqui-tous human pathogen that causes disease in immunocom-promised patients. The JCPyV genome is composed of an early region and a late region, which are physically sepa-rated by the ...
Anzivino, Elena, Bellizzi, Anna, Palamara, ANNA TERESA, Pietropaolo, Valeria Antonietta, Prezioso, Carla, Rodio, DONATELLA MARIA, Scribano, D, Trancassini, Maria   +7 more
core   +1 more source

Establishing, versus Maintaining, Brain Function: A Neuro-computational Model of Cortical Reorganization after Injury to the Immature Brain [PDF]

Journal of the International Neuropsychological Society, 17:1030-1038, 2011, 2011
The effect of age at injury on outcome after acquired brain injury (ABI) has been the subject of much debate. Many argue that young brains are relatively tolerant of injury. A contrasting viewpoint due to Hebb argues that greater system integrity may be required for the initial establishment of a function than for preservation of an already-established
arxiv   +1 more source

The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]

, 2017
Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna, Ibba, G, Palamara, ANNA TERESA, Pietropaolo, Valeria Antonietta, White, Mk, Wollebo, Hs   +5 more
core   +1 more source

Mild progressive multifocal leukoencephalopathy after switching from natalizumab to ocrelizumab

Neurology: Neuroimmunology & Neuroinflammation, 2020
Objective To describe the disease course of carryover progressive multifocal leukoencephalopathy (PML) after switching from natalizumab to ocrelizumab in 2 patients with relapsing-remitting MS.
Alyssa A. Toorop, Z. V. van Lierop, E. Strijbis, C. Teunissen, A. Petzold, M. Wattjes, F. Barkhof, B. D. de Jong, Z. V. van Kempen, J. Killestein   +9 more
semanticscholar   +1 more source

Treatment of progressive multifocal leukoencephalopathy [PDF]

Journal of Neurology, 2019
Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive demyelinating disease of the central nervous system caused by John Cunningham polyomavirus (JCV), a globally seroprevelant virus that commonly causes a silent or benign infection. However, in immunocompromised patients JCV can be reactivated. In this situation, most organs remain
Daniel Castle, Neil Robertson
openaire   +3 more sources

Natalizumab affects T-cell phenotype in multiple sclerosis: implications for JCV reactivation [PDF]

, 2016
The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV ...
A Bellizzi, A Laroni, A Petrovic, Ada Francia, Alessandra D’Abramo, Alessandra Oliva, Anna Bellizzi, B Engelhardt, BL Padgett, C Bozic, C Tornatore, Claudia D’Agostino, Claudio Maria Mastroianni, D Jing, E Pucci, Elena Anzivino, EM Frohman, EM Johnson, Enrico Millefiorini, EO Major, EO Major, F Serana, F Taguchi, G Defer, H Bonig, K Khalili, L Börnsen, L Gorelik, LJ Marshall, M Niino, Manuela Morreale, Marco Iannetta, Maria Antonella Zingaropoli, Maria Rosa Ciardi, MC Monaco, ME Hemler, P Maenetje, RA Rudick, RM Ransohoff, Robert Shin Fujinami, RR Lobb, S Beltrami, SA Houff, SA Sadiq, Sara Lo Menzo, Simona Pontecorvo, T Van Loy, Valeria Pietropaolo, Vincenzo Vullo, WJ Atwood, Y Chen, Ö Yaldizli   +51 more
core   +3 more sources

Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

New England Journal of Medicine, 2019
Background Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain infection that is caused by the JC virus and is typically fatal unless immune function can be restored.
I. Cortese, P. Muranski, Yoshimi Enose-Akahata, S. Ha, Bryan R. Smith, M. Monaco, C. Ryschkewitsch, E. Major, J. Ohayon, M. Schindler, E. Beck, L. Reoma, S. Jacobson, D. Reich, A. Nath   +14 more
semanticscholar   +1 more source