Results 61 to 70 of about 8,307 (217)

The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]

, 2017
Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna, Ibba, Gabriele, Palamara, Anna T., Pietropaolo, Valeria, White, Martyn K., Wollebo, Hassen, Wollebo|   +6 more
core   +1 more source

Progressive Multifocal Leukoencephalopathy (PML) – a Case Report.

Pulse, 2014
Progressive Multifocal Leukoencephalopathy (PML) is a rare and usually fatal viral disease occurring almost exclusively in people with severe immune deficiency. This is a demyelinating disease of the central nervous system (CNS) that usually leads to death or severe disability.
J Alam, BS Khan
openaire   +2 more sources

The Effect of Ocrelizumab on Anti‐JC Virus Antibody Index

Brain and Behavior, Volume 16, Issue 5, May 2026.
Synopsis: This study of 553 MS patients found that anti‐JC virus (JCV) antibody indices remain stable during the first 2 years of ocrelizumab treatment. While peripheral B‐cells were significantly depleted and serum immunoglobulins (IgG, IgM, IgA) showed modest declines, the JCV antibody index did not change significantly.
Akash Virupakshaiah, Alexander J. Gill, Vinicius A. Schoeps, Emma Wilson, James Wilson, David Do, Amit Bar‐Or, Dina Jacobs, Joseph R. Berger   +8 more
wiley   +1 more source

Multifocal Leukoencephalopathy

Pediatric Neurology Briefs, 1994
A 15-year-old boy with Wiskott-Aldrich syndrome complicated by progressive multifocal leukoencephalopathy (PML) is reported from the University of Miami School of Medicine, FL, and the National Institute of Neurological Disorders and Stroke, Bethesda, MD.
J Gordon Millichap
doaj   +1 more source

Dynamics of complete responses (CRs) in patients with relapsed or refractory follicular lymphoma (R/R FL) treated with odronextamab in the ELM‐2 study

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Complete response (CR) is an important treatment goal in follicular lymphoma (FL). In relapsed or refractory (R/R) FL, CR rates decline, and disease progression accelerates with each treatment line, with particularly poor outcomes in patients with high‐risk features.
Stefano Luminari, Ana Jiménez‐Ubieto, Geoffrey Chong, David Tucker, Srikanth Ambati, Chinjune Lin, Hesham Mohamed, Jurriaan Brouwer‐Visser, Chetachi Akunna Otele, Giovanni Antico, Jose C. Villasboas   +10 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in a lung transplant recipient

Clinical Case Reports
Key Clinical Message Progressive multifocal leukoencephalopathy (PML) is a rare and fatal demyelinating disease of the central nervous system (CNS). The case we describe highlights the importance of considering a diagnosis of PML early (
Jason Sakizadeh, Michael J. Davis, Lauren Fontana   +2 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy selectively affecting Broca's and Wernicke's areas in an immunocompetent patient: A case report

Radiology Case Reports, 2023
Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal, demyelinating disease of the central nervous system. The disease almost exclusively presents in immunosuppressed patients, such as those with acquired immunodeficiency syndrome, a ...
Renaid B. Kim, BS, David N. Irani, MD, John Kim, MD   +2 more
doaj   +1 more source

Cost‐Effectiveness of Dimethyl Fumarate Versus Teriflunomide in Patients With Relapsing‐Remitting Multiple Sclerosis (RRMS) in Iran

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Multiple sclerosis (MS) is an autoimmune disorder that damages the myelin sheath on nerve fibers in the central nervous system, leading to axonal damage and neuron death. This study aimed to assess the cost‐effectiveness of dimethyl fumarate compared with teriflunomide as first‐line oral medications for patients with ...
Maryam Poursadeghfard, Yasin Farjah, Mehdi Rezaee, Nastaran Momtahan, Mohammad Hossein Morowvat, Ahmad Gholami, Khosro Keshavarz   +6 more
wiley   +1 more source

JCV-specific T-cells producing IFN-gamma are differently associated with PmL occurrence in HIV patients and liver transplant recipients [PDF]

, 2015
Aim of this work was to investigate a possible correlation between the frequency of JCV-specific T-cells and PML occurrence in HIV-infected subjects and in liver transplant recipients.
Agrati, C, Angrisani, M, Baldini, F, Berno, G, Bolognese, A., Bordoni, V, Capobianchi, Mr, Cimini, E, Colasanti, M, Di Cello, P, Ettorre, Gm, Giancola, Ml, Izzo, Luciano, Izzo, Paolo, Pugliese, Federico   +14 more
core  

Dual Therapy with Cidofovir and Mirtazapine for Progressive Multifocal Leukoencephalopathy in a Sarcoidosis Patient

Case Reports in Neurology, 2011
Background: Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease caused by JC virus (JCV) reactivation in immunocompromised patients.
Jae Hyun Park, Sookyung Ryoo, Hyun Jin Noh, Jung Min Seo, Hyun Hee Kang, Ji Soo Shin, Sang Won Seo, Duk L. Na   +7 more
doaj   +1 more source