Results 41 to 50 of about 8,307 (217)

Does Mefloquine (Lariam®) Therapy Improve the Prognosis of Human JC Polyomavirus-Induced Progressive Multifocal Leukoencephalopathy? [PDF]

Journal of Biomedical & Clinical Research, 2014
Progressive multifocal leukoencephalopathy (PML) is ademyelinating disease caused by infection with Polyomavirus hominis 2, popularly known as JC virus (JCV).
Zlatko Kalvatchev, Iliya Tsekov
doaj   +3 more sources

Virus demyelination [PDF]

, 2003
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC ...
Fazakerley, John K, Walker, Robert
core   +1 more source

Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate [PDF]

, 2015
BACKGROUND: Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence.
Antje Bornemann, Felix Bischof, Nele Dammeier, Till-Karsten Hauser, Victoria Schubert   +4 more
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Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report [PDF]

, 2010
Background To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir. Case Presentation A 35-year-old immunocompetent man who developed progressive hemianopsia, aphasia, and limb weakness underwent repeated MRI ...
Halvor Naess, Solveig Glad, Anette Storstein, Christine H Rinaldo, Sverre J Mørk, Kjell-Morten Myhr, Hans Hirsch, N Khanna, L Kappos, KR Carson, KR Carson, JR Berger, A De Luca, JF Viallard, JF Viallard, MT Roberts, CM Marra, K Tan, H Linda, CB Drachenberg, A Egli, RW Price, P Cinque, G Meintjes, A Langer-Gould, RL Cardenas, J Berenguer   +26 more
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Progressive multifocal leukoencephalopathy after immunochemotherapy: a case report highlighting pembrolizumab limitations [PDF]

Precision and Future Medicine
A 55-year-old woman with stage IV follicular lymphoma developed progressive multifocal leukoencephalopathy (PML) during rituximab maintenance therapy following bendamustine-rituximab induction.
Dayeon Seo, Seoung Wan Chae, Kyung Hoon Lee, Du-Young Kang, Yun-Gyoo Lee   +4 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review [PDF]

Encephalitis, 2021
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection due to reactivation of John Cunningham virus (JCV). The diagnosis depends on evidence from clinical, imaging, and virologic studies.
Sungjoon Yoon, Yongmoo Kim, Seon-Jae Ahn, Kon Chu   +3 more
doaj   +1 more source

Frequent Infection of Cerebellar Granule Cell Neurons by Polyomavirus JC in Progressive Multifocal Leukoencephalopathy [PDF]

, 2009
Progressive multifocal leukoencephalopathy (PML) occurs most often in immunosuppressed individuals. The lesions of PML result from astrocyte and oligodendrocyte infection by the polyomavirus JC (JCV); JCV has also been shown to infect and destroy ...
Beckwith, Curt, Bell, Jeanne E., Cheng, Yi Min, Joseph, Jeffrey T., Kesari, Santosh, Koralnik, Igor J., Stopa, Edward, Wuethrich, Christian   +7 more
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Can pulmonary sarcoidosis trigger a progressive multifocal leukoencephalopathy? Considerations from a case series and a review of literature

Clinical Case Reports, 2018
Key Clinical Message Progressive multifocal leukoencephalopathy (PML) is a severe infectious brain disease with lethal outcome mainly seen in immunocompromised subjects.
Irene Gamperl, Christian Enzinger, Alexander Pichler, Michael Feichtinger, Thomas Schlager, Elisabeth Fertl   +5 more
doaj   +1 more source

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses

Cell Reports, 2017
Summary: Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of ...
Eileen M. Geoghegan, Diana V. Pastrana, Rachel M. Schowalter, Upasana Ray, Wei Gao, Mitchell Ho, Gary T. Pauly, Dina M. Sigano, Campbell Kaynor, Ellen Cahir-McFarland, Benoit Combaluzier, Jan Grimm, Christopher B. Buck   +12 more
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JCPyV NCCR analysis in PML patients with different risk factors: exploring common rearrangements as essential changes for neuropathogenesis

Virology Journal, 2020
Background During severe immunosuppression or treatment with specific biological drugs, human polyomavirus JC (JCPyV) may establish a lytic infection in oligodendrocytes, leading to progressive multifocal leukoencephalopathy (PML).
Maria Rosa Ciardi, Maria Antonella Zingaropoli, Marco Iannetta, Carla Prezioso, Valentina Perri, Patrizia Pasculli, Miriam Lichtner, Gabriella d’Ettorre, Marta Altieri, Antonella Conte, Valeria Pietropaolo, Claudio Maria Mastroianni, Vincenzo Vullo   +12 more
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