Results 21 to 30 of about 5,030 (173)

Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy

Emerging Infectious Diseases, 2019
Antibodies against PD1 have been used to treat progressive multifocal leukoencephalopathy (PML), a rare brain disease caused by JC virus. We used these antibodies (nivolumab) to treat PML in 3 kidney transplant recipients.
Chloé Medrano, François Vergez, Catherine Mengelle, Stanislas Faguer, Nassim Kamar, Arnaud Del Bello   +5 more
doaj   +1 more source

Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma

eJHaem, 2020
Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine‐rituximab. In this report, treatment with pembrolizumab successfully inhibited the clinical progression of PML by promoting ...
Inès Dufour, Thierry Duprez, Marie Wertz, Pascale Saussoy, Nathalie Ackermans, Souraya El Sankari, Vincent van Pesch, Eric Van Den Neste   +7 more
doaj   +1 more source

Progressive Multifocal Leukoencephalopathy in an Immunocompetent Patient

Case Reports in Neurology, 2013
Background: Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients.
Krisztina K. Johansen, Sverre H. Torp, Jana Rydland, Jan O. Aasly   +3 more
doaj   +1 more source

Does Mefloquine (Lariam®) Therapy Improve the Prognosis of Human JC Polyomavirus-Induced Progressive Multifocal Leukoencephalopathy? [PDF]

Journal of Biomedical & Clinical Research, 2014
Progressive multifocal leukoencephalopathy (PML) is ademyelinating disease caused by infection with Polyomavirus hominis 2, popularly known as JC virus (JCV).
Zlatko Kalvatchev, Iliya Tsekov
doaj   +3 more sources

Progressive multifocal leukoencephalopathy after immunochemotherapy: a case report highlighting pembrolizumab limitations [PDF]

Precision and Future Medicine
A 55-year-old woman with stage IV follicular lymphoma developed progressive multifocal leukoencephalopathy (PML) during rituximab maintenance therapy following bendamustine-rituximab induction.
Dayeon Seo, Seoung Wan Chae, Kyung Hoon Lee, Du-Young Kang, Yun-Gyoo Lee   +4 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review [PDF]

Encephalitis, 2021
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection due to reactivation of John Cunningham virus (JCV). The diagnosis depends on evidence from clinical, imaging, and virologic studies.
Sungjoon Yoon, Yongmoo Kim, Seon-Jae Ahn, Kon Chu   +3 more
doaj   +1 more source

Can pulmonary sarcoidosis trigger a progressive multifocal leukoencephalopathy? Considerations from a case series and a review of literature

Clinical Case Reports, 2018
Key Clinical Message Progressive multifocal leukoencephalopathy (PML) is a severe infectious brain disease with lethal outcome mainly seen in immunocompromised subjects.
Irene Gamperl, Christian Enzinger, Alexander Pichler, Michael Feichtinger, Thomas Schlager, Elisabeth Fertl   +5 more
doaj   +1 more source

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses

Cell Reports, 2017
Summary: Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of ...
Eileen M. Geoghegan, Diana V. Pastrana, Rachel M. Schowalter, Upasana Ray, Wei Gao, Mitchell Ho, Gary T. Pauly, Dina M. Sigano, Campbell Kaynor, Ellen Cahir-McFarland, Benoit Combaluzier, Jan Grimm, Christopher B. Buck   +12 more
doaj   +1 more source

JCPyV NCCR analysis in PML patients with different risk factors: exploring common rearrangements as essential changes for neuropathogenesis

Virology Journal, 2020
Background During severe immunosuppression or treatment with specific biological drugs, human polyomavirus JC (JCPyV) may establish a lytic infection in oligodendrocytes, leading to progressive multifocal leukoencephalopathy (PML).
Maria Rosa Ciardi, Maria Antonella Zingaropoli, Marco Iannetta, Carla Prezioso, Valentina Perri, Patrizia Pasculli, Miriam Lichtner, Gabriella d’Ettorre, Marta Altieri, Antonella Conte, Valeria Pietropaolo, Claudio Maria Mastroianni, Vincenzo Vullo   +12 more
doaj   +1 more source

Progressive Multifocal Leukoencephalopathy Associated to Multiple Sclerosis Therapies: Review of the literature [PDF]

Romanian Journal of Neurology, 2015
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection associated with the reactivation of the JC virus, causing a severe demyelination within the central nervous system in patients with immunosuppression caused by disease or ...
Ana-Maria Vladila, Dan-Andrei Mitrea, Sanda Maria Nica, Ioan Buraga   +3 more
doaj   +1 more source