Results 91 to 100 of about 5,411,820 (260)

Functional clinical outcomes in multiple sclerosis: Current status and future prospects [PDF]

, 2015
For decades, the Expanded Disability Status Scale (EDSS) has been the principal measure of disability in clinical trials in patients with multiple sclerosis (MS) and in clinical practice.
Deleu, Dirk T., Dahdaleh, Maurice P., Alroughani, Raed, Inshasi, Jihad Said, Yamout, Bassem I., Bohlega, Saeed A., Sahraian, Mohammed A., AlTahan, Abdulrahman M., Rieckmann, Peter, Al-Jumah, Mohammed A., Alsharoqi, Isa Ahmed, Deleu, Dirk, Aljumah, Mohammed, Daif, Abdulkader Kader M., Karabudak, Rana, Alroughani, Raed A., Sahraian, Mohammad Ali, Inshasi, Jihad S., Dahdaleh, Maurice, Alsharoqi, I. Ahmed, Amous, Amer, Daif, Abdulkader   +21 more
core   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Factors associated with the progression of disability (EDSS) among MS patients

eNeurologicalSci
Background: Multiple sclerosis is a chronic, inflammatory, autoimmune disease of the central nervous system. Accumulating neurological disability has a substantial impact on the lives of patients with MS.
Anibal Arteaga-Noriega, Jose Zapata-Berruecos, Johanna Gutiérrez-Vargas, John Camilo Garcia, Diego Rojas-Gualdron, Manuela Restrepo-Botero   +5 more
doaj   +1 more source

No evidence of a significant role for CTLA-4 in multiple sclerosis [PDF]

, 2006
Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore
Maranian, M, Hensiek, A, Sawcer, S, Roxburgh, R, Seaman, S, Compston, A, Yeo, T, Deans, J   +7 more
core  

Three cases of herpes zoster radiculitis in MS patients treated with natalizumab [PDF]

, 2016
Natalizumab was the first FDA-approved monoclonal antibody for the treatment of multiple sclerosis (MS). We report on 3 natalizumab-treated patients who developed herpes zoster infections.
Khoury, Samia J., Yamout, Bassem I., Zeineddine, Maya M., Taha, Ali J., Abou-Zeid, Nuhad E.   +4 more
core   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Result of rehabilitation treatment in patients with multiple sclerosis

Acta Médica del Centro, 2020
Introduction: multiple sclerosis is a demyelinating, degenerative, chronic and progressive disease of the central nervous system that constitutes one of the causes of neurological disability in young adults.
Maikel Herrera Broche, María Eneida Avello Olivert, Claristel Blanco Ramos, Osvaldo Fraga Ramírez, Loraine Navarro Jiménez, Lázaro Aurelio Vásquez Gómez   +5 more
doaj  

Analysis of the time to sustained progression in Multiple Sclerosis using generalised linear and additive models [PDF]

, 2003
The course of multiple sclerosis (MS) is generally difficult to predict. This is due to the great inter-individual variability with respect to symptoms and disability status.
Hellriegel, B., Neiss, A., Neiss, Albrecht, Hellriegel, Barbara, Gehrmann, U., Fahrmeir, Ludwig   +5 more
core   +1 more source

Anti‐CD20 Discontinuation Versus Continuation in People Aged Over 50 With Non‐Active Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy.
Alexia Moukhine, Fabien Rollot, Romain Casey, Nicolas Collongues, Sandra Vukusic, Guillaume Mathey, Anne Laure Dubessy, Jonathan Ciron, Jérôme De Seze, Aurélie Ruet, Pierre Labauge, Arnaud Kwiatkowski, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun‐Frenay, David Axel Laplaud, Eric Berger, Eric Thouvenot, Jean Pelletier, Abdullatif Al Khedr, Olivier Casez, Bertrand Bourre, Abir Wahab, Laurent Magy, Jean‐Philippe Camdessanché, Ines Doghri, Solène Moulin, Mariana Sarov Rivière, Karolina Hankiewicz, Amélie Dos Santos, Corinne Pottier, Eric Manchon, Jennifer Aboab, Maia Tchikviladze, Thomas David, Gilles Edan, Emmanuelle Le Page, Laure Michel, Anne Kerbrat, OFSEP Investigators   +40 more
wiley   +1 more source