Results 161 to 170 of about 5,411,820 (260)

High Diagnosis Rate for Nonimmune Hydrops Fetalis With Prenatal Clinical Genome: Expanded Results From the Hydrops‐Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Nonimmune hydrops fetalis (NIHF) is characterized by abnormal fluid accumulation in ≥ 2 fetal compartments and may be genetic. The incremental diagnostic yield of prenatal exome sequencing (ES) for NIHF following a negative standard workup was previously explored on 22 cases.
Stephanie M. Rice, Mona M. Makhamreh, Sascha Wodoslawsky, Mariella Toro, Elizabeth Critchlow, Brandy Firman, Ruby Liu, Babi Ramesh Nallamilli, Madhuri Hegde, Seth I. Berger, Huda B. Al‐Kouatly   +10 more
wiley   +1 more source

Insights and challenges on animal models for progressive multiple sclerosis. [PDF]

J Neuroinflammation
Nalepa IF, Haahr NO, Bekiaris V, Jakobsen MR, Asuni AA, Benmamar-Badel A.   +5 more
europepmc   +1 more source

General Practice Utilisation for Adults With Neurological Disability Who Are National Disability Insurance Scheme Participants in Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT Most adults with neurological disability rely on general practitioners for managing and preventing health complications. This study analysed patterns of general practice service utilisation among National Disability Insurance Scheme (NDIS) participants with neurological disability and compared these with people who are not NDIS participants ...
Stacey Oliver, Robin A. Ramme, Avinash Kondiboyina, Karina Gardner, Adam McLeod, Stephen Weeding, Christopher Pearce, Jacinta Douglas, Di Winkler   +8 more
wiley   +1 more source

Reduced Paramagnetic Rim Visibility Signals Lesion Aging and Tissue Degeneration in Progressive Multiple Sclerosis: Impact on Clinical Trials. [PDF]

Neurol Neuroimmunol Neuroinflamm
Sacco S, Zhao H, Cheng S, Akula AV, Luskin E, Zhang J, Manouvakhova O, Cooper TP, Stern W, Block VJ, Virupakshaiah A, Gomez R, Santaniello A, Sati P, Papinutto N, Bove R, Gelfand JM, Goodin DS, Green AJ, Oksenberg J, Waubant E, Wilson MR, Zamvil SS, as the University of California, San Francisco MS-EPIC Team, Cree BAC, Hauser SL, Henry RG.   +27 more
europepmc   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Ocrelizumab Discontinuation After Recurrent Serious Infections in Clinically Stable Primary Progressive Multiple Sclerosis: A Case Report. [PDF]

Cureus
Lo T, Hassan L, Wilson S, Seri R, Hang S.   +4 more
europepmc   +1 more source

Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo, Barbara Iazzolino, Cristina Moglia, Umberto Manera, Enrico Matteoni, Sara Cabras, Giorgio Pellegrino, Emilio Minerva, Vita Passidomo, Rosario Vasta, Gabriele Mora, Fabrizio D’Ovidio, Antonio Canosa, Andrea Calvo, Adriano Chiò   +14 more
wiley   +1 more source

A CSF disease-associated macrophage signature defines progressive multiple sclerosis. [PDF]

J Neuroinflammation
Börsch AL, Riethues F, Schulte-Mecklenbeck A, Wang X, Heming M, Lu IN, Müller-Miny L, Wiendl H, Gross CC, Bernard-Valnet R, Meyer Zu Hörste G.   +10 more
europepmc   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Effect of intrathecal injection of mesenchymal stem cell-neural progenitors on cerebrospinal fluid biomarkers in progressive multiple sclerosis. [PDF]

Stem Cells Transl Med
Harris VK, Jiang A, Ricciarini S, Jagid N, McCormick M, Kizilbash C, Sadiq SA.   +6 more
europepmc   +1 more source