Results 181 to 190 of about 5,411,820 (260)

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain

Annals of Neurology, EarlyView.
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola, Maija Saraste, Edoardo Pedrini, Joel Tuomaala, Luzia Buchholz, Markus Matilainen, Johanna Lindenberg, Eeva‐Christine Brockmann, Maria Sofia Martire, Sofia Sandgren, David Leppert, Jens Kuhle, Tanja Kuhlmann, Martina Absinta, Laura Airas   +14 more
wiley   +1 more source

Disability profiles in progressive multiple sclerosis reflect pathology distribution, independent of clinical phenotype. [PDF]

Brain Commun
De Meo E, Jolly AE, Ganzetti M, Prados Carrasco F, Kanber B, Stutters J, McManus D, Kazlauskaite A, Craveiro L, Eshaghi A, Cole J, Chard D, Barkhof F.   +12 more
europepmc   +1 more source

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72-Year Journey of Pediatric-Onset to Secondary Progressive Multiple Sclerosis. [PDF]

Clin Case Rep
Etemadifar M, Dehghani A, Rahimi M, Ghandehari A, Salari M.   +4 more
europepmc   +1 more source

A novel multiplexed biomarker panel reveals key molecular pathways in progressive multiple sclerosis. [PDF]

Brain Commun
Heiss CN, Novakova L, Axelsson M, Tan K, Pola I, Traichel W, Pesämaa I, Johnsson M, Sandgren S, Malmeström C, Benedet AL, Zetterberg H, Lycke JN, Fruhwürth S, Rosenstein I.   +14 more
europepmc   +1 more source

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

Animal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang, Bo Wang, Mengya Wang, Haizhan Tang, Mingjian Liu, Da Zheng, Zhongyi Zhai, Jiahang Li, Jinyang Xie, Chaofan Jin, Jingjie Hu, Zhenmin Bao   +11 more
wiley   +1 more source

Divergent Immunological and Neurotrophic Responses to CD20 Depletion in Relapsing and Progressive Multiple Sclerosis. [PDF]

Neurol Ther
Körner GM, Möllenkamp TM, Jendretzky KF, Kretschmer JR, Pietschmann ACS, Siemer JM, von Hörsten J, Konen FF, Schwenkenbecher P, Hümmert MW, Bachhuber F, Tumani H, Jacobs R, Skripuletz T, Gingele S.   +14 more
europepmc   +1 more source

Lung Ultrasound for the Detection of Radiologic Progression of Interstitial Lung Abnormalities in Patients With Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Interstitial lung disease (ILD) is an important extra‐articular manifestation of rheumatoid arthritis (RA) associated with high mortality and morbidity. Lung ultrasonography (LUS) has recently emerged as a possible screening tool. We assessed the role of LUS in monitoring radiologic progression and the development of new interstitial lung ...
Marie Vermant, Valerie Van Ballaer, Joseph Jacob, Tine Follet, Ryoko Egashira, Kenny Anseele, Heleen Cypers, Laurens J. De Sadeleer, Nico De Crem, Tinne Goos, Barbara Neerinckx, Veerle Taelman, Nathalie Veyt, Alexandros Kalkanis, Patrick Verschueren, Wim A. Wuyts   +15 more
wiley   +1 more source

Primary Progressive Multiple Sclerosis With Acute Neurologic Deterioration Secondary to Metabolic Derangements and Medication Effects. [PDF]

Cureus
Boddakayala V, Mirnateghi A, Nakov KM, Pattathan M.   +3 more
europepmc   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Longitudinal magnetic resonance spectroscopy study of metabolite changes over 2 years in relapsing and primary progressive multiple sclerosis treated with ocrelizumab. [PDF]

Mult Scler
MacMillan EL, Russell-Schulz B, Alejo G, Harp C, Cameron B, Winger R, Jia S, Herman A, Kassam J, Waine M, Vavasour IM, Cross H, Tam R, Traboulsee AL, Carruthers R, Kolind SH.   +15 more
europepmc   +1 more source