Results 101 to 110 of about 11,777 (218)
Journal of Diabetes Research, Volume 2026, Issue 1, 2026.Diabetic nephropathy (DN), a predominant cause of end‐stage renal disease (ESRD), is primarily driven bfigolic disturbances and mitochondrial dysfunction. Apolipoprotein M (ApoM), a protein associated with high‐density lipoprotein (HDL), is notably downregulated in DN and is correlated with a decline in renal function.
Tianlei Chen, Min Yang, Hannah Wesley
wiley +1 more source
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. [PDF]
The EMBO Journal, 1994 The two major classes of antigen receptors on murine B lymphocytes, mIgM and mIgD, are both contained in a complex with two additional molecules, Ig-alpha and Ig-beta, which permit signal transduction. Accordingly, early biochemical events after antigen binding to either receptor are similar; biological effects, however, are different.
M, Terashima +6 more
openaire +2 more sources
Prohibitin: an unexpected role in sex dimorphic functions [PDF]
Biology of Sex Differences, 2016 Sex differences are known to exist in adipose and immune functions in the body, and sex steroid hormones are known to be involved in sexually dimorphic biological and pathological processes related to adipose-immune interaction. However, our knowledge of proteins that mediate such differences is poor. Two novel obese mice models, Mito-Ob and m-Mito-Ob,
Nguyen, K. H +2 more
openaire +2 more sources
Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4. [PDF]
PLoS ONE, 2011 We previously reported that the degradation of prohibitin by the SCF(Skp2B) ubiquitin ligase results in a defect in the activity of p53. We also reported that MMTV-Skp2B transgenic mice develop mammary gland tumors that are characterized by an increased ...
Harish Chander +4 more
doaj +1 more source
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao +5 more
wiley +1 more source
Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-β pathways
Journal of Ovarian Research, 2017 Background Ovarian epithelial tumor (OET) is a silent disease of late diagnosis and poor prognosis. Currently treatment options are limited and patient response to treatment is difficult to predict so there is a serious need to delineate the real ...
Nour M. El-Etreby +2 more
doaj +1 more source
EFSA Journal, Volume 24, Issue 1, January 2026.Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ) +28 more
wiley +1 more source
The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]
, 2020 Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core +1 more source
Репродуктивная эндокринологияBackground. COVID-19 pandemic is accompanied by a considerable number of morbidity cases among pregnant women. Certain knowledge has been accumulated about the histopathological features of the placenta during SARS-CoV-2 infection.
G.S. Manasova, Y.O. Stasii
doaj +1 more source
Dose-Response, 2018 To evaluate microbeam radiation therapy (MRT), for brain tumor treatment, the bystander effect in nonirradiated companion animals was investigated.
Richard Smith +9 more
doaj +1 more source