Results 61 to 70 of about 5,465,036 (281)

Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus

Frontiers in Genome Editing
Influenza A virus (IAV) infection is initiated by hemagglutinin (HA), a glycoprotein exposed on the virion’s lipid envelope that undergoes cleavage by host cell proteases to ensure membrane fusion, entry into the host cells, and completion of the viral ...
Giovana Ciacci Zanella, Giovana Ciacci Zanella, Celeste A. Snyder, Bailey L. Arruda, Kristin Whitworth, Kristin Whitworth, Erin Green, Ravikanth Reddy Poonooru, Bhanu P. Telugu, Bhanu P. Telugu, Amy L. Baker   +10 more
doaj   +1 more source

ALLERGIC BRONCHIAL ASTHMA IN CHILDHOOD – NATURAL HISTORY, THE ROLE OF CHRONIC INFLAMMATION [PDF]

Romanian Medical Journal, 2019
The inflammatory response in the airways of patients with asthma involves the interaction between the respiratory epithelium, the innate immune system and the adaptive immunity, which initiates and maintains the chronic inflammatory response ...
Simona Maria Borta, Imola Donath-Miklos, Romana Olivia Popeţiu, Maria Puşchiţă   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Development of Antimicrobial α‐AApeptides that Suppress Proinflammatory Immune Responses [PDF]

ChemBioChem, 2014
AbstractHerein we describe the development of a new class of antimicrobial and anti‐inflammatory peptidomimetics: cyclic lipo‐α‐AApeptides. They have potent and broad‐spectrum antibacterial activity against a range of clinically relevant pathogens, including both multidrug‐resistant Gram‐positive and Gram‐negative bacteria.
Shruti, Padhee, Christina, Smith, Haifan, Wu, Yaqiong, Li, Namitha, Manoj, Qiao, Qiao, Zoya, Khan, Chuanhai, Cao, Hang, Yin, Jianfeng, Cai   +9 more
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Immune characterization of a Colombian family cluster with SARS-CoV-2 infection

Biomédica: revista del Instituto Nacional de Salud, 2021
Introduction: Immunological markers have been described during COVID-19 and persist after recovery. These immune markers are associated with clinical features among SARSCoV-2 infected individuals.
Wbeimar Aguilar-Jiménez, Lizdany Flórez-Álvarez, Daniel S. Rincón, Damariz Marín-Palma, Alexandra Sánchez-Martínez, Jahnnyer Martínez, María Isabel Zapata, John D. Loaiza, Constanza Cárdenas, Fanny Guzmán, Paula A. Velilla, Natalia A. Taborda, Wildeman Zapata, Juan C. Hernández, Francisco J. Díaz, María T. Rugeles   +15 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Analysis of proinflammatory cytokine responses in Takayasu arteritis

Archives of Rheumatology
Objectives: This study aimed to investigate the expression of proinflammatory cytokines under long-term T helper (Th) 17 cell inducing conditions in Takayasu arteritis (TAK), a granulomatous vasculitis with adaptive immune responses. Patients and methods: This cross-sectional study was conducted between May 2014 and April 2017.
Deniz, Rabia, Tulunay-Virlan, Aysın, Ture Ozdemir, Filiz, Unal, Ali Ugur, Ozen, Gulsen, Alibaz-Oner, Fatma, Aydin-Tatli, Imren, Direskeneli, Haner   +7 more
openaire   +2 more sources

Chemical Synthesis and Proinflammatory Responses of Monophosphoryl Lipid A Adjuvant Candidates [PDF]

European Journal of Organic Chemistry, 2009
AbstractLipopolysaccharides (LPS), which are structural components of the outer‐surface membrane of Gram‐negative bacteria, trigger innate immune responses through activation of Toll‐like receptor 4 (TLR4). Such responses may be exploited for the development of adjuvants and in particular monophosphoryl lipid A (MPLA) obtained by controlled hydrolysis ...
Maiti, Kaustabh K., DeCastro, Michael, El-Sayed, Abu-Baker M Abdel-Aal, Foote, Matthew I, Wolfert, Margreet A., Boons, Geert-Jan   +5 more
openaire   +5 more sources

Amplifying the innate immune response : cell-cell propagation of proinflammatory signals during bacterial infection [PDF]

, 2012
The enteroinvasive bacterium Shigella flexneri uses multiple secreted effector proteins to downregulate interleukin-8 (IL-8) expression in infected epithelial cells. Nevertheless, massive IL-8 secretion is observed in shigellosis. In this thesis, a novel
Kasper, Christoph Alexander
core   +1 more source