Results 41 to 50 of about 5,465,036 (281)

The Role Of Serum Amyloid A In Inflammatory Disease - Proinflammatory Mediator Or Inert Biomarker? [PDF]

, 2010
: Neutrophils are phagocytes of the innate immune system with prominent roles in host defense and are also believed to be important in autoimmune diseases such as rheumatoid arthritis (RA) by accumulating in inflamed joints and contribute to tissues ...
Björkman, Lena
core   +1 more source

Extrachromosomal circular DNA (eccDNA): an emerging star in cancer

Biomarker Research, 2022
Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and ...
Ruomeng Li, Ying Wang, Jing Li, Xikun Zhou   +3 more
doaj   +1 more source

GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis [PDF]

Frontiers in Immunology, 2020
Objectives: GM-CSF is a pro-inflammatory cytokine with multiple actions predominantly on myeloid cells. Enhanced GM-CSF expression by lymphocytes from patients with Ankylosing Spondylitis (AS) has recently been described, however, its potential pathogenic role(s) in AS are unknown.
Shi, H, Chen, L, Ridley, A, Zaarour, N, Brough, I, Caucci, C, Smith, JE, Bowness, P   +7 more
openaire   +4 more sources

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Solymosi, Norbert, Cotman, Carl, Hrabovszky, Erik, Likó, István, Liposits, Zsolt, Sárvári, Miklós, Berchtold, Nicole, Kalló, Imre   +7 more
core   +3 more sources

The Inflammatory Response in Human Keratinocytes Exposed to Cinnamaldehyde Is Regulated by Nrf2

Antioxidants, 2022
Keratinocytes (KC) play a crucial role in epidermal barrier function, notably through their metabolic activity and the detection of danger signals. Chemical sensitizers are known to activate the transcription factor nuclear factor (erythroid-derived 2 ...
Romain Vallion, Kévin Hardonnière, Abderrahmane Bouredji, Marie-Hélène Damiens, Claudine Deloménie, Marc Pallardy, Pierre-Jacques Ferret, Saadia Kerdine-Römer   +7 more
doaj   +1 more source

The proinflammatory cytokine response to coagulation and endotoxin in whole blood [PDF]

Blood, 1996
Acute inflammatory illnesses, including the sepsis syndrome, often include a component of coagulation. A human whole blood culture system was developed so that the relationship between coagulation activation and cytokine responses in the presence or absence of lipopolysaccharide (LPS) could be evaluated.
K, Johnson, L, Aarden, Y, Choi, E, De Groot, A, Creasey   +4 more
openaire   +2 more sources

Toxoplasma gondii Infection Induces High Mobility Group Box 1 Released from Mouse Macrophages

Frontiers in Microbiology, 2017
High mobility group box 1 (HMGB1) is abundantly expressed in intracellular engaged DNA binding ability. However, more importantly, it is a weapon against infection through proinflammatory response and immune regulation while released to extracellular ...
Qun Liu, Hui Wang, Hui Wang, Muzi Li, Jing Liu, Jianhai Xu, Qian Han   +6 more
doaj   +1 more source

P . aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro

BMC Genomics, 2022
Background Lung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. During infection, airway epithelial cells secrete proinflammatory mediators that participate in the recruitment of immune cells.
Emel Sen-Kilic, Annalisa B. Huckaby, F. Heath Damron, Mariette Barbier   +3 more
doaj   +1 more source

Triggering the immune response by proinflammatory cytokines

Journal of Biosciences, 1997
What determines whether or not an immune response takes place? The older view that it is only the presence or absence of T cells bearing appropriate receptors that matters has been replaced by one which lays at least equal emphasis on inflammation: whether or not antigen-presenting cells become activated and secrete proinflammatory cytokines.
Thomas Kamradt, Avrion Mitchison
openaire   +1 more source

Impact of Low Interferon-γ and IL-10 Levels on TNF-α and IL-6 Production by PHA-Induced PBMCs in Type 2 Diabetes Mellitus

Journal of Inflammation Research, 2020
Rona Kartika,1 Dyah Purnamasari,2 Saraswati Pradipta,1 Rahma A Larasati,3 Heri Wibowo4 1Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia; 2Division of Metabolic Endocrinology and Diabetes ...
Kartika R, Purnamasari D, Pradipta S, Larasati RA, Wibowo H   +4 more
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