Results 31 to 40 of about 5,465,036 (281)

RETRACTED: Rosmarinic Acid Attenuates the Lipopolysaccharide-Provoked Inflammatory Response of Vascular Smooth Muscle Cell via Inhibition of MAPK/NF-κB Cascade

Pharmaceuticals, 2022
Rosmarinic acid (RA) is a phenolic compound that has several bioactivities, such as anti-inflammatory and antioxidant activities. Here, we further investigate the anti-inflammatory effect of RA on rat A7r5 aortic smooth muscle cells with exposure to ...
Ching-Pei Chen, You-Cian Lin, Yu-Hui Peng, Han-Min Chen, Jiun-Tsai Lin, Shao-Hsuan Kao   +5 more
doaj   +1 more source

Proinflammatory cytokine responses in patients with psoriasis

European Cytokine Network, 2014
Psoriasis is one of the most common, immune-mediated, chronic inflammatory skin diseases. Proinflammatory cytokines play an important pathogenetic role at a local level.To assess whether the proinflammatory cytokines IL-1β, IL-6, IL-17, IL-22 and TNF-α are released systemically during psoriasis.Peripheral blood mononuclear cells (PBMCs) were isolated ...
Kouris, A., Pistiki, A., Katoulis, A., Georgitsi, M., Giatrakou, S., Papadavid, E., Netea, M.G., Stavrianeas, N., Giamarellos-Bourboulis, E.J.   +8 more
openaire   +3 more sources

The Effects of Apigenin-Biosynthesized Ultra-Small Platinum Nanoparticles on the Human Monocytic THP-1 Cell Line

Cells, 2019
Generally, platinum nanoparticles (PtNPs) are considered non-toxic; however, toxicity depends on the size, dose, and physico-chemical properties of materials.
Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Min-Hee Kang, Jin-Hoi Kim   +3 more
doaj   +1 more source

Lipopolysaccharide Downregulates CD163 Expression to Inhibit PRRSV Infection via TLR4-NF-κB Pathway

Frontiers in Microbiology, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to induce proinflammatory cytokine production and modulate the host interferon (IFN) system.
Zhenbang Zhu, Hui Zhang, Xiaoxiao Zhang, Sheng He, Wenjuan Dong, Xiaoying Wang, Yaosheng Chen, Xiaohong Liu, Chunhe Guo   +8 more
doaj   +1 more source

Different infective forms trigger distinct immune response in experimental Chagas disease. [PDF]

, 2012
Although metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface.
Olindo Assis Martins-Filho, Carneiro Cláudia Martins, Martins-Filho, Olindo Assis, Alexandre Barbosa Reis, Cláudia Martins Carneiro, Francisco Amanda Fortes, Washington Luiz Tafuri, Carvalho, Andrea Teixeira, Machado Evandro Marques de Meneses, Nogueira, Nívia Carolina, Franscisco, Amanda Fortes, Evandro Marques de Meneses Machado, Vieira, Paula Melo de Abreu, Fonseca, Kátia da Silva, Francisco, Amanda Fortes, Andrea Teixeira-Carvalho, Paula Melo de Abreu Vieira, Nogueira, N??via Carolina, Machado, Evandro Marques de Menezes, Vieira Paula Melo de Abreu, Machado, Evandro Marques de Meneses, Tafuri, Washington Luiz, Reis Alexandre Barbosa, Teixeira-Carvalho Andrea, Reis, Alexandre Barbosa, Martins-Filho Olindo Assis, Nívia Carolina Nogueira, Kátia da Silva Fonseca, Carvalho, Andréa Teixeira de, Nogueira Nívia Carolina, Amanda Fortes Francisco, Tafuri Washington Luiz, Teixeira-Carvalho, Andrea, Carneiro, Cláudia Martins, Martins Filho, Olindo Assis, Fonseca Kátia da Silva   +35 more
core   +2 more sources

Supplemented pulsatilla decoction alleviated ulcerative colitis by attenuating the pro-inflammatory response and modifying gut microbiota in mice [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
The present study aimed to combine Portulaca oleracea L with PD to compose a new formula supplemented PD (SPD), and evaluate its effect on ulcerative colitis (UC).
Hongyu DAI, Zhihai CHANG, Haidong WANG, Jinjie GUO, Guizhen CHEN, Liangliang LI, Shoujun ZUO, Pengtao SONG, Fang LIU, Haiju DONG   +9 more
doaj   +1 more source

Oral administration of PCBs induces proinflammatory and prometastatic responses [PDF]

Environmental Toxicology and Pharmacology, 2008
Exposure to specific congeners of polychlorinated biphenyls (PCBs) can induce proinflammatory alterations, which may contribute to the formation of blood-borne tumor metastasis. The main aim of the present study was to establish an experimental model of PCB exposure in which PCBs are administered by oral gavage, which resembles the human exposure ...
Sandor, Sipka, Sung-Yong, Eum, Kwang Won, Son, Shifen, Xu, Vasileios G, Gavalas, Bernhard, Hennig, Michal, Toborek   +6 more
openaire   +2 more sources

The pharmacokinetic-pharmacodynamic model of azithromycin for lipopolysaccharide-induced depressive-like behavior in mice. [PDF]

PLoS ONE, 2013
A mechanism-based model was developed to describe the time course of lipopolysaccharide-induced depressive-like behavior and azithromycin pharmacodynamics in mice.
Kun Hao, Qu Qi, Haiping Hao, Guangji Wang, Yuancheng Chen, Yan Liang, Lin Xie   +6 more
doaj   +1 more source

Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide [PDF]

Molecular and Cellular Biology, 2006
Activation of interleukin-1 (IL-1) receptor (IL-1R), Toll-like receptor 2 (TLR2), and TLR4 triggers NF-kappaB and mitogen-activated protein kinase (MAPK)-dependent signaling, thereby initiating immune responses. Tollip has been implicated as a negative regulator of NF-kappaB signaling triggered by these receptors in in vitro studies.
Didierlaurent, Arnaud, Brissoni, Brian, Velin, Dominique, Aebi, Natalia, Tardivel, Aubry, Käslin, Edgar, Sirard, Jean Claude, Angelov, Georgi, Tschopp, Jürg, Burns, Kimberly   +9 more
openaire   +4 more sources

The Use of Acute Immunosuppressive Therapy to Improve Antibiotic Efficacy against Intracellular Staphylococcus aureus

Microbiology Spectrum, 2022
Interactions between Staphylococcus aureus and the host immune system can have significant impacts on antibiotic efficacy, suggesting that targeting and modulating the immune response to S.
Jenna E. Beam, Sophie Maiocchi, Ana Cartaya, Sarah E. Rowe, Edward S. M. Bahnson, Brian P. Conlon   +5 more
doaj   +1 more source