Results 51 to 60 of about 5,465,036 (281)
G3: Genes, Genomes, Genetics, 2016 The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), plays an important immunomodulatory role, regulating transcription of genes in the innate and adaptive immune system.
Silvia N. Kariuki +4 more
doaj +1 more source
Microglia: Agents of the CNS Pro-Inflammatory Response
Cells, 2020 The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have increased our understanding ...
José A. Rodríguez-Gómez +9 more
doaj +1 more source
Keratinocyte proinflammatory responses to adherent and nonadherent group A streptococci [PDF]
Infection and Immunity, 1997 The gram-positive bacterium Streptococcus pyogenes (group A streptococcus) is the causative agent of a wide variety of suppurative infections of cutaneous tissues. Previous analyses have demonstrated that the M protein of S. pyogenes is an adhesin that directs the attachment of the streptococcus to keratinocytes in the skin.
B, Wang +3 more
openaire +2 more sources
Role of interleukin-17A in endodontic disease
Medical Journal of Babylon, 2023 Background: Endodontic disease is a complicated condition marked by inflammation of the apical tissues and is influenced by microbial, immunological, and environmental variables. Inflammatory cells, proinflammatory, and immunoregulatory cytokines are all
Tuqa’a Rahman Ghanim +2 more
doaj +1 more source
Redox Biology, 2014 High-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type 2 diabetes (T2D). Previous study shows fatty acid-induced accumulation of damaged, reactive oxygen species (ROS)-generating mitochondria, and this in turn ...
Sijun Yang +5 more
doaj +1 more source
A Multimethod Approach to Understanding the Association Between Interpersonal Stress, Proinflammatory Response, and Suicidality [PDF]
, 2022 Suicide is the second leading cause of death among adolescents and young adults. Peer-related interpersonal stress increases suicide risk within this age group.
Defayette, Annamarie Bailey
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in Oncology, 2018 Polyphenols have tumoricidal effects via anti-proliferative, anti-angiogenic and cytotoxic mechanisms and have recently been demonstrated to modulate the immune response through their anti- or pro- oxidant activity. Nevertheless, it remains controversial
Paola Lasso +8 more
doaj +1 more source
Inflammasome Activation: A Keystone of Proinflammatory Response in Obstructive Sleep Apnea
IBJ Plus, 2022 Introduction: As the mechanism that links obstructive sleep apnea (OSA) with the regulation of inflammatory response is not well known, it is important to understand the inflammasome activation, mainly of NLRP3 (nucleotide-binding oligomerization domain-like receptor 3).To assess the NLRP3 activity in patients with severe OSA and to identify its role ...
Elena Díaz-García +10 more
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source