Results 51 to 60 of about 636,811 (278)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Fulfilling international obligations of the Republic of Kazakhstan toward achieving carbon neutrality: Legal challenges and prospects [PDF]

Environmental Economics
Type of the article: Research Article AbstractMany countries face the need for structural transformation of their economies, particularly in terms of environmental and climate aspects.
Aigul Nukusheva, Aitugan Abdizhami, Saida Assanova, Guldana Karzhassova, Kargash Akhmetova   +4 more
doaj   +1 more source

Cooperation, domination and colonisation: the Israeli-Palestinian Joint Water Committee [PDF]

, 2013
Do there exist instances of international (water) policy coordination which are so unequal that they should not even be considered 'cooperation'? This article argues, on both theoretical and empirical grounds, that this is indeed so.
Selby, Jan
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Speech-language therapy stimulation in children with Down’s syndrome

Revista CEFAC
Objective: to analyze the contributions of speech-language therapy to the language development of children with Down syndrome (DS). Methods: eleven children with DS participated in the research.
Mariane Sousa Regis, Ivonaldo Leidson Barbosa Lima, Larissa Nadjara Alves Almeida, Giorvan Ânderson dos Santos Alves, Isabelle Cahino Delgado   +4 more
doaj   +1 more source

Patient-Centered Care in Small Primary Care Practices in New York City: Recognition Versus Reality

Journal of Primary Care & Community Health, 2017
Background: The Primary Care Information Project (PCIP) is a program administered by the New York City Department of Health and Mental Hygiene to help primary care providers adopt a fully functional electronic health record (EHR) and focus on population ...
Margaret M. Paul, Stephanie L. Albert, Tod Mijanovich, Sarah C. Shih, Carolyn A. Berry   +4 more
doaj   +1 more source

Effect of a computerized decision support system on the treatment approach of stage III or IV pressure injury in patients with spinal cord injury: a feasibility study

BMC Health Services Research, 2023
Background Stage III and IV pressure injuries (PIs) in patients with spinal cord injury (SCI) require complex interdisciplinary and interprofessional treatment approaches that are difficult to implement.
Anke Scheel-Sailer, Kamran Koligi, Patricia Lampart, Carina Fähndrich, Hans Peter Gmünder, Stefan Metzger, Dirk Schaefer, Klaus Schmitt, Stefan Stalder, Reto Wettstein, Armin Gemperli   +10 more
doaj   +1 more source

Retooling Waterfront Governance in the New York-New Jersey Harbor: Case Studies from Waterfront Cities [PDF]

, 2013
Who is in charge of the waterfront? Everybody and nobody. The scramble of commissions and task forces in the wake of Superstorm Sandy brought the challenge of waterfront governance into sharp relief.

core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Building Medical Homes in State Medicaid and CHIP Programs [PDF]

, 2009
Presents strategies, best practices, and lessons learned from ten states' efforts to advance the medical home model of comprehensive and coordinated care in Medicaid and Children's Health Insurance Programs in order to improve quality and contain ...
Mary Takach, Neva Kaye
core