Results 71 to 80 of about 37,320 (265)

Empirical Issues and Challenges for Multilevel Governance: The Case of the 2010 Vancouver Olympic Winter Games

Revue Gouvernance, 2018
How did a large network of over 600 actors successfully organize itself to serve a mega project dominated by three levels of government, even as control rested with a non-profit entity, included other sectors, and the governments involved did not ...
Milena Parent, Christian Rouillard, Jean-Loup Chappelet   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Deconstructing synergistic carbon reduction mechanisms in large-scale construction governance: A Monte Carlo simulation based on a cross-scale model

Ain Shams Engineering Journal
This study develops a cross-scale collaborative optimization model to explore synergistic carbon emission reduction (SCER) mechanisms in governance networks for large-scale construction projects.
Zhizhe Zheng, Yikun Su, Junhao Liu
doaj   +1 more source

GIS-Driven Platforms for Territorial Project Monitoring: Evidence from Taza Province, Morocco [PDF]

E3S Web of Conferences
The management and monitoring of territorial development projects in Morocco face persistent challenges due to fragmented data systems, weak coordination, and the lack of real-time evaluation mechanisms.
Akallouch Adil, Al Mashoudi Ayoub, Mahjoub Aziz, Ziani Mouloud, ElYakoubi Said, Hamjik Mohamed   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Effectiveness of the integrated school project and implications for the reform of the Moroccan education system: An approach based on managerial levers [PDF]

Knowledge & Performance Management
Type of the article: Research Article Educational reform in Morocco continues to face persistent challenges related to learning outcomes, territorial disparities, and the limited effectiveness of centralized policy instruments.
Hamid Zahir, Mohammed Bougroum, Abdelilah Sadqaoui   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Decoding the Indian data governance model: Relooking at Aadhaar

Social Sciences and Humanities Open
In its recently adorned G20 presidency, India showcased its Digital Public Infrastructure (DPI) model to the world. It consists of three primary layers: 1. The identity layer that is the Aadhaar with the Biometric Identity System, 2.
Anjana Sasi
doaj   +1 more source

New directions in earth system governance research

Earth System Governance, 2019
The Earth System Governance project is a global research alliance that explores novel, effective governance mechanisms to cope with the current transitions in the biogeochemical systems of the planet.
Sarah Burch, Aarti Gupta, Cristina Y.A. Inoue, Agni Kalfagianni, Åsa Persson, Andrea K. Gerlak, Atsushi Ishii, James Patterson, Jonathan Pickering, Michelle Scobie, Jeroen Van der Heijden, Joost Vervoort, Carolina Adler, Michael Bloomfield, Riyanti Djalante, John Dryzek, Victor Galaz, Christopher Gordon, Renée Harmon, Sikina Jinnah, Rakhyun E. Kim, Lennart Olsson, Judith Van Leeuwen, Vasna Ramasar, Paul Wapner, Ruben Zondervan   +25 more
doaj   +1 more source