Results 71 to 80 of about 1,375,385 (285)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Approximations of solutions for a class of conditionally well-posed integro-differential equations

Учёные записки Казанского университета: Серия Физико-математические науки
In this article, for a specific class of conditionally well-posed integro-differential equations in a novel pair of weighted Sobolev spaces, an alternative method for constructing approximations (particularly finite-dimensional ones) to the solution of ...
J. R. Agachev, M. Yu. Pershagin
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Comparative Analysis of Wavelet Bases for Solving First-Kind Fredholm Integral Equations

Computation
This research presents a comparative analysis of numerical methods for solving first-kind Fredholm integral equations using the Bubnov–Galerkin method with various wavelet and orthogonal polynomial bases.
Nurlan Temirbekov, Dinara Tamabay, Aigerim Tleulesova, Tomiris Mukhanova   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Three-Term Hybrid Conjugate Gradient Projection Method for Solving Convex Constrained Nonlinear Monotone Equations and Applications

IEEE Access
This paper presents a new three-term hybrid conjugate gradient projection method for handling large-scale convex-constrained nonlinear monotone equations that are prevalent in fields such as engineering optimization, data science, and signal processing ...
Xiaowei Fang, Yufan Rao, Jingchi Wang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Teaching medical students hematopathology: a randomized crossover study comparing direct inspection by light microscope versus projected images

Frontiers in Medicine
BackgroundStudents’ ability to diagnose various blood disorders could be substantially improved by continuously reviewing approaches toward teaching hematology.
Sultan Alqahtani, Sultan Alqahtani, Sami Al-Nasser, Sami Al-Nasser, Sajida Agha, Sajida Agha, Mohamud S. Mohamud   +6 more
doaj   +1 more source

A Projection Model of Neutrosophic Numbers for Multiple Attribute Decision Making of Clay-Brick Selection [PDF]

Neutrosophic Sets and Systems, 2016
Brick plays a significant role in building construction. So we should use the effective mathematical decision making tool to select quality clay-bricks for building construction.
Jiqian Chen, Jun Ye
doaj