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Resistant prolactinomas

Journal of Endocrinological Investigation, 2011
Prolactinomas are the most common hormonally active pituitary tumors and are usually successfully treated with dopamine agonists. A small proportion, however, appears not to respond to such treatment and such cases are termed resistant prolactinomas. Resistance is generally defined as failure to achieve normoprolactinemia and inability to induce tumor ...
Vasilev, Vladimir   +4 more
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The Prolactinoma Problem

New England Journal of Medicine, 1979
The secretion of prolactin is tonically inhibited by the hypothalamus, an effect mediated by the release of a prolactin inhibitory factor into the pituitary blood supply.1 Much newly acquired evidence points to dopamine as the principal inhibitory regulator.2 Specific dopamine-containing nerve tracts in the hypothalamus terminate on the blood vessels ...
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Malignant prolactinoma

Acta Endocrinologica, 1992
Malignant prolactinoma is a rare entity and only a few cases have been published. The diagnostic criteria and the clinical course remain unclear. We present a case of malignant prolactinoma in a woman with a 30-year duration of the disease. In the terminal stage of the disease the prolactinoma metastasized to the left eye, the prolactin level reaching ...
M, Berezin   +4 more
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Surgery for prolactinoma

Best Practice & Research Clinical Endocrinology & Metabolism
Prolactinomas (lactotroph pituitary neuroendocrine tumours) account for almost half of all pituitary tumours and significantly affect quality of life. Dopamine agonists (DA) are effective in achieving biochemical control in prolactinoma, but rates of long-term biochemical remission off therapy are low, and there is an increasing recognition of a broad ...
Mendel, Castle-Kirszbaum, Ann, McCormack
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Prolactinoma in Children

Archives of Pediatrics & Adolescent Medicine, 1987
Sir .—I read with great interest the report by Huseman and colleagues 1 on a child with prolactinoma. The letter was extremely valuable in pointing the efficacy of bromocriptine therapy even in large tumors. It is reassuring to read that this conservative approach to treatment is as efficacious in children as it is in adults.
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Update in prolactinomas.

The Netherlands journal of medicine, 2010
Prolactinomas are a frequent cause of gonadal dysfunction and infertility, especially in women. Dopamine agonists are first-line therapy and their efficacy in the treatment of prolactinomas is well established. Current challenges related to the management of prolactinomas remain in the recurrence of the disease after withdrawal of dopamine agonists ...
Kars, M.   +3 more
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Prolactinomas and Pregnancy

Pituitary, 2005
Prolactinomas are the most frequent pituitary tumors. Treatment of infertility in such tumors usually is very successful. On the other hand, reports of pituitary tumor growth during pregnancy have been described since bromocriptine started to be used.
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Prolactinoma in pregnancy

Best Practice & Research Clinical Endocrinology & Metabolism, 2011
Prolactinomas commonly cause infertility and treatment usually restores ovulation and fertility. The dopamine agonists are the preferred mode of treatment, with cabergoline generally being preferred to bromocriptine because of its higher therapeutic ratio.
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Hyperprolactinemia and prolactinoma

2014
Prolactinomas are the most frequent pituitary adenomas. In patients with prolactinomas the primary cause of hyperprolactinemia is excessive and autonomic production of prolactin by lactotroph cells. In other conditions, except in case of macroprolactinemia, hyperprolactinemia is secondary to circumstances that stimulate secretion of prolactin by ...
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Prolactinomas

Archives of Internal Medicine, 1979
In the past ten years, hyperprolactinemia has been implicated as a possible cause of several common medical problems. One of the first recognized was the so-called amenorrhea-galactorrhea syndrome. Subsequently it was learned that not all patients with elevated prolactin levels have galactorrhea 1 (only about 20% of hyperprolactinemic women and even ...
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