Results 11 to 20 of about 1,987,388 (288)
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer
eLife, 2022 Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated by mechanical stiffness or inflammatory signals directs the reciprocal ...
Yuexin Wang +10 more
doaj +1 more source
Non-proliferation and counter-proliferation [PDF]
, 2018 European approaches to the proliferation of nuclear, biological, and chemical weapons-the so-called weapons of mass destruction (WMD)-have undergone a profound transformation during the last few decades. This chapter will trace the varying European policy responses to WMD proliferation over time and examine how European security doctrines have evolved ...
+6 more sources
Nature Communications, 2018 Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu +10 more
doaj +1 more source
Cells, 2020 The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular ...
Anna Tutusaus +5 more
doaj +1 more source
Российский офтальмологический журнал, 2019 Purpose: to study the role of cellular immunity in the development of retinopathy of prematurity (ROP).Material and methods. 87 children were tested, including 60 with III — V stage ROP and posterior aggressive retinopathy that had gestational age from ...
L. M. Balashova +6 more
doaj +1 more source
Frontiers in Microbiology, 2022 The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li +7 more
doaj +1 more source
α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization
eLife, 2022 The centrosome composed of a pair of centrioles (mother and daughter) and pericentriolar material, and is mainly responsible for microtubule nucleation and anchorage in animal cells.
Dandan Ma +9 more
doaj +1 more source
Nature Communications, 2017 Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly ...
Ning Huang +7 more
doaj +1 more source
Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming
eLife, 2018 Understanding how cellular identity naturally interconverts with high efficiency and temporospatial precision is crucial for regenerative medicine. Here, we revealed a natural midgut-to-renal lineage conversion event during Drosophila metamorphosis and ...
Ke Xu +4 more
doaj +1 more source
Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis
Cells, 2022 Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres +3 more
doaj +1 more source