Results 21 to 30 of about 3,456,235 (361)
Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease
BMC Genomics, 2018 Background Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth.
Guoliang Lyu +11 more
doaj +1 more source
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer
eLife, 2022 Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated by mechanical stiffness or inflammatory signals directs the reciprocal ...
Yuexin Wang +10 more
doaj +1 more source
A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
Nature Communications, 2016 Drosophila RNAi libraries are commonly used to perform large-scale functional genetics screens in vivo. Here the authors find that a subset of lines from the VDRC KK RNAi line cause false-positive enhancement of the Hippo pathway, and provide a strain ...
Joseph H.A. Vissers +3 more
doaj +1 more source
Induction of endothelial cell proliferation by recombinant and microparticle-tissue factor involves β1-integrin and extracellular signal regulated kinase activation [PDF]
, 2010 Objective: Increased levels of circulating tissue factor (TF) in the form of microparticles increase the risk of thrombosis. However, any direct influence of microparticle-associated TF on vascular endothelial cell proliferation is not known.
Collier, Mary E. W., Ettelaie, Camille
core +1 more source
Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation [PDF]
, 2017 Cell proliferation has generally been considered dispensable for anteroposterior extension of embryonic axis during vertebrate gastrulation. Signal transducer and activator of transcription 3 (Stat3), a conserved controller of cell proliferation ...
Liu, Yinzi +2 more
core +4 more sources
A Prize for Proliferation [PDF]
Cell, 2001 As an avid reader of the Economist, I was disappointed by their suggestion that the Nobel committee had “blown” it in giving this year's prize for medicine and physiology to the discoverers of Cdks and not to those who had just sequenced the human genome.
openaire +3 more sources
Cells, 2020 The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular ...
Anna Tutusaus +5 more
doaj +1 more source
Global proliferation of cephalopods [PDF]
Current Biology, 2016 Human activities have substantially changed the world's oceans in recent decades, altering marine food webs, habitats and biogeochemical processes [1]. Cephalopods (squid, cuttlefish and octopuses) have a unique set of biological traits, including rapid growth, short lifespans and strong life-history plasticity, allowing them to adapt quickly to ...
Doubleday, Zoë A. +10 more
openaire +7 more sources
Nature Communications, 2018 Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
Guoliang Lyu +10 more
doaj +1 more source
Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System. [PDF]
, 2019 Mammalian cardiac Purkinje fibers (PFs) are specified from ventricular trabecular myocardium during mid-gestation and undergo limited proliferation before assuming their final form.
Evangelista, Melissa +5 more
core +2 more sources