Results 21 to 30 of about 1,987,388 (288)

A comparative study of of T regulatory cells numbers (CD4⁺CD25^highFoxP3⁺CD127^low) in patients under 1 year of age with cataract, glaucoma, and retinopathy of prematurity (review of the own studies)

Медицинская иммунология
Potential involvement of immune system in pathophysiology of congenital glaucoma, cataract, and retinopathy of prematurity (ROP) in infants has been suggested. However, its understanding still remains limited.
L. M. Balashova, Yu. D. Kuznetsova, S. V. Lesovoy, M. A. Alvarez, A. A. Balashov, D. R. Cherkashin, E. P. Kantarzhi, S. N. Bykovskaya, Zh. M. Salmasi   +8 more
doaj   +1 more source

Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer

Molecules, 2022
Piezo1 was originally identified as a mechanically activated, nonselective cation ion channel, with significant permeability to calcium ions, is evolutionally conserved, and is involved in the proliferation and development of various types of cells, in ...
Yuexin Wang, Zhiyuan Zhang, Qiuli Yang, Yejin Cao, Yingjie Dong, Yujing Bi, Guangwei Liu   +6 more
doaj   +1 more source

Proliferation [PDF]

Thrombosis Research, 2017
Henri H, Versteeg, Marc, Rodger
  +7 more sources

Sphingomyelinases and Liver Diseases

Biomolecules, 2020
Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling ...
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa   +3 more
doaj   +1 more source

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

Nature Communications, 2022
Chromosomal structural variations induced by CRISPR/Cas hinder its application in clinics. Here, the authors fuse Cas9 with optimized TREX2 to generate Cas9TX, which can prevent perfect repair and inhibit repeated cleavage.
Jianhang Yin, Rusen Lu, Changchang Xin, Yuhong Wang, Xinyu Ling, Dong Li, Weiwei Zhang, Mengzhu Liu, Wutao Xie, Lingyun Kong, Wen Si, Ping Wei, Bingbing Xiao, Hsiang-Ying Lee, Tao Liu, Jiazhi Hu   +15 more
doaj   +1 more source

The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice

Cell Reports, 2022
Summary: The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus; however, our understanding of the physiological roles of PT in sperm is very limited.
Xiao-Zhen Zhang, Lin-Lin Wei, Hui-Juan Jin, Xiao-Hui Zhang, Su-Ren Chen   +4 more
doaj   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III

Genome Biology, 2020
Background The relationship between transcription and the 3D chromatin structure is debated. Multiple studies have shown that transcription affects global Cohesin binding and 3D genome structures.
Yongpeng Jiang, Jie Huang, Kehuan Lun, Boyuan Li, Haonan Zheng, Yuanjun Li, Rong Zhou, Wenjia Duan, Chenlu Wang, Yuanqing Feng, Hong Yao, Cheng Li, Xiong Ji   +12 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A novel method for genetic transformation of yeast cells using oligoelectrolyte polymeric nanoscale carriers

BioTechniques, 2013
The genetic transformation of target cells is a key tool in modern biological research, as well as in many gene therapy and biotechnology applications. Here we describe a new method for delivery of DNA into several industrially important species of yeast,
Yevhen Filyak, Nataliya Finiuk, Nataliya Mitina, Oksana Bilyk, Vladimir Titorenko, Olesya Hrydzhuk, Alexander Zaichenko, Rostyslav Stoika   +7 more
doaj   +1 more source