Results 41 to 50 of about 3,096 (170)

Immunogenicity of a recombinant vaccine against Lawsonia intracellularis in mice

Veterinary Vaccine
Lawsonia intracellularis is the cause of proliferative enteropathy (PE), which is highly prevalent in swine, causing substantial economic losses to the sector. The available PE vaccines have protection-related limitations. Therefore, the objective of the
Neida Lucia Conrad, Vitória Sequeira Gonçalves Zorzi, Ilana Mazzoleni, Ana Vitória Costa, Renan Eugênio Araújo Piraine, Fábio Pereira Leivas Leite   +5 more
doaj   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Indolent NK cell proliferative lesion mimicking NK/T cell lymphoma in the gallbladder

Human Pathology: Case Reports, 2016
Natural killer (NK) cell-associated lymphoproliferative disorder includes NK/T cell lymphoma, nasal type and aggressive NK cell leukemia which exhibit poor outcomes. However, benign NK cell proliferative lesion has been recognized in the gastrointestinal
Su Hyun Hwang, Joon Seong Park, Seong Hyun Jeong, Hyunee Yim, Jae Ho Han   +4 more
doaj   +1 more source

Detection of Diagnostic Antibodies in Immune‐Mediated Diseases: A Focus on Antigens and Technologies

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review explores autoantibody detection in immune‐mediated diseases, highlighting autoantigens including post‐translational modifications. We compared enzyme‐linked immunosorbent assay and indirect immunofluorescence with automated chemiluminescence platforms.
Silvia Bracci, Feliciana Real‐Fernandez, Federico Pratesi, Francesca Nuti, Paolo Rovero, Anna Maria Papini   +5 more
wiley   +1 more source

Characterization of translocon proteins in the type III secretion system of Lawsonia intracellularis

Veterinary Research, 2023
Lawsonia intracellularis, the etiologic agent of proliferative enteropathy (PE), is an obligate intracellular Gram-negative bacterium possessing a type III secretion system (T3SS), which enables the pathogen to translocate effector proteins into targeted
Beibei Huang, Zihe Zhu, Yimin Dai, Chengxian Yan, Jingyu Xu, Lingling Sun, Qinghua Zhang, Xuejiao An, Fenju Lai   +8 more
doaj   +1 more source

In Silico Evaluation of Lawsonia intracellularis Genes Orthologous to Genes Associated with Pathogenesis in Other Intracellular Bacteria

Microorganisms
Proliferative enteropathy is an enteric disease caused by the bacterium Lawsonia intracellularis, which affects several species of domestic and wild animals. The mechanisms underlying the mechanisms employed by L.
Mirtha E. Suarez-Duarte, Renato L. Santos, Carlos E. R. Pereira, Talita P. Resende, Matheus D. Araujo, Paula A. Correia, Jessica C. R. Barbosa, Ricardo P. Laub, Diego L. N. Rodrigues, Flavia F. Aburjaile, Roberto M. C. Guedes   +10 more
doaj   +1 more source

Comparative transcriptional analysis of homologous pathogenic and non-pathogenic Lawsonia intracellularis isolates in infected porcine cells. [PDF]

PLoS ONE, 2012
Lawsonia intracellularis is the causative agent of proliferative enteropathy. This disease affects various animal species, including nonhuman primates, has been endemic in pigs, and is an emerging concern in horses.
Fabio A Vannucci, Douglas N Foster, Connie J Gebhart   +2 more
doaj   +1 more source

A novel case of autosomal recessive CARD11 loss‐of‐function underlying impaired antiviral immunity and a review of literature

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
We report on a patient homozygous for a novel autosomal recessive loss‐of‐function CARD11 variant, with susceptibility to live attenuated virus (LAV) vaccines and impaired clearance of multiple naturally acquired respiratory viral infections. Inborn errors of immunity affecting the CARD11‐BCL10‐MALT1 (CBM) complex should be considered in individuals ...
Hamish Anderson, Cecilia Verryt, Paula Keating, Thomas Saunders, Samuel Dalton, Barry D Hock, Liping Goddard, Kylie Drake, Anja Werno, John O'Donnell, Jeffrey R Stinson, Andrew L Snow, Kuang‐Chih Hsiao   +12 more
wiley   +1 more source

Increased Serum Levels of Dickkopf‐1 and Sclerostin as WNT Signaling Pathway Inhibitors in Celiac Disease Patients

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background Celiac disease (CD) is an autoimmune enteropathy. The WNT signaling pathway acts in adult intestinal epithelium maintenance. Aim To evaluate the level of two WNT antagonists, including dikkopf‐1 (Dkk‐1) and sclerostin, in CD patients compared to controls. Methods A total of 43 cases and 45 controls were enrolled in this case‐control
Mohammed Nibras Thabit Al‐Ani, Saad Kadhim Taher Yahya, Majid Dastorani, Hanie Mirkarimi, Sima Besharat, Marie Saghaeian Jazi   +5 more
wiley   +1 more source

Growth in Paediatric Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Impaired linear growth is a common, clinically meaningful complication of paediatric inflammatory bowel disease (IBD), particularly Crohn's disease, arising from the combination of chronic intestinal inflammation, undernutrition, dysfunction of the growth hormone–insulin‐like growth factor‐1 axis, and iatrogenic effects such as glucocorticoid ...
Firas Rinawi, Séamus Hussey, Eileen Crowley, Dror S. Shouval, Iva Hojsak   +4 more
wiley   +1 more source