Results 151 to 160 of about 12,701 (190)
Abstract This research describes the engineering of chitosan nanoparticles (CS NPs) via ionic gelation to encapsulate Ajwah seed extract (ASE), repurposing a plant waste product for its documented antioxidant and anticancer potential. Physicochemical analysis confirmed the formation of stable nanoparticles with hydrodynamic diameters between 152.3 and ...
Jailan E. Elhalawani +2 more
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Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
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LC-MS/MS method for proline-glycine-proline and acetylated proline-glycine-proline in human plasma
Journal of Chromatography B, 2023The extracellular cellular matrix (ECM) maintains tissue structure and regulates signaling functions by continuous degradation and remodeling. Inflammation or other disease conditions activate proteases including matrix metalloproteinases (MMPs) that degrade ECM proteins and in particular generate fragments of collagen and elastin, some of which are ...
Ekta Tiwary +5 more
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Control of Proline Biosynthesis by Proline and Proline Analogues
Nature, 1966MICRO-ORGANISMS prevent over-production of amino -acids by two mechanisms: (a) end-product inhibition of the action of the first specific enzyme in the biosynthetic sequence, and (b) inhibition of the synthesis of all the enzymes in the sequence (enzyme repression)1,2. A number of growth-inhibitory analogues of normal protein amino-acids, besides being
H, Tristram, C F, Thurston
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Proline and proline derivatives as anticonvulsants
General Pharmacology: The Vascular System, 19891. The anticonvulsant properties of L-proline, of proline derivatives (trans-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, 3,4-dehydro-D,L-proline) and of D- and L-pipecolic acid were studied alone and in combination with vigabatrin (R/S-4-aminohex-5-enoic acid).
S, Sarhan, N, Seiler
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Acta Crystallographica Section C Crystal Structure Communications, 2005
In the structure of DL-proline, C5H9NO2, the molecules are connected via classical intermolecular N-H...O hydrogen bonds involving the amine and carboxyl groups [N...O = 2.7129 (15) and 2.8392 (16) A], and form chains along the b-axis direction and parallel to (-101). The chains are linked into sheets via weak non-classical hydrogen bonds.
Sunnie, Myung +3 more
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In the structure of DL-proline, C5H9NO2, the molecules are connected via classical intermolecular N-H...O hydrogen bonds involving the amine and carboxyl groups [N...O = 2.7129 (15) and 2.8392 (16) A], and form chains along the b-axis direction and parallel to (-101). The chains are linked into sheets via weak non-classical hydrogen bonds.
Sunnie, Myung +3 more
openaire +4 more sources
Chemical Reviews
Within the canonical repertoire of the amino acid involved in protein biogenesis, proline plays a unique role as an amino acid presenting a modified backbone rather than a side-chain. Chemical structures that mimic proline but introduce changes into its specific molecular features are defined as proline analogues.
Vladimir Kubyshkin, Marina Rubini
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Within the canonical repertoire of the amino acid involved in protein biogenesis, proline plays a unique role as an amino acid presenting a modified backbone rather than a side-chain. Chemical structures that mimic proline but introduce changes into its specific molecular features are defined as proline analogues.
Vladimir Kubyshkin, Marina Rubini
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Acta Tropica, 2021
The PE/PPE proteins encoded by seven percent (7%) of Mycobacterium tuberculosis (Mtb) genome are the chief constituents to pathogen's virulence reservoir. The fact that these genes have evolved along ESX secretory system in pathogenic Mtb strains make their investigation very intriguing.
null Medha, Sadhna Sharma, Monika Sharma
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The PE/PPE proteins encoded by seven percent (7%) of Mycobacterium tuberculosis (Mtb) genome are the chief constituents to pathogen's virulence reservoir. The fact that these genes have evolved along ESX secretory system in pathogenic Mtb strains make their investigation very intriguing.
null Medha, Sadhna Sharma, Monika Sharma
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Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1997
Proline is unique among the 20 amino acids due to its cyclic structure. This specific conformation imposes many restrictions on the structural aspects of peptides and proteins and confers particular biological properties upon a wide range of physiologically important biomolecules.
D F, Cunningham, B, O'Connor
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Proline is unique among the 20 amino acids due to its cyclic structure. This specific conformation imposes many restrictions on the structural aspects of peptides and proteins and confers particular biological properties upon a wide range of physiologically important biomolecules.
D F, Cunningham, B, O'Connor
openaire +2 more sources

