Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line. [PDF]
PLoS ONE, 2018 L-Proline is a multifunctional amino acid that plays an essential role in primary metabolism and physiological functions. Proline is oxidized to glutamate in the mitochondria and the FAD-containing enzyme proline oxidase (PO) catalyzes the first step in ...
Pamela Cappelletti +5 more
doaj +5 more sources
Involvement of proline oxidase (PutA) in programmed cell death of Xanthomonas. [PDF]
PLoS ONE, 2014 Xanthomonas campestris strains have been reported to undergo programmed cell death (PCD) in a protein rich medium. Protein hydrolysates used in media such as nutrient broth comprise of casein digest with abundance of proline and glutamate. In the current
Surbhi Wadhawan +2 more
doaj +4 more sources
Prolidase-proline oxidase axis is engaged in apoptosis induction by birch buds flavonol santin in endometrial adenocarcinoma cell line [PDF]
Frontiers in Molecular Biosciences, 2023 Cancer of the corpus uteri and cervix uteri, collectively ranks second among new cancer cases in women after breast cancer. Therefore, investigation of new anticancer agents and identifying new molecular targets presents a challenge to improve ...
Lukasz Szoka +3 more
doaj +2 more sources
Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy. [PDF]
Amino Acids, 2021 AbstractRecent studies on the regulatory role of amino acids in cell metabolism have focused on the functional significance of proline degradation. The process is catalysed by proline dehydrogenase/proline oxidase (PRODH/POX), a mitochondrial flavin-dependent enzyme converting proline into ∆1-pyrroline-5-carboxylate (P5C).
Palka J, Oscilowska I, Szoka L.
europepmc +4 more sources
NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells. [PDF]
Int J Mol Sci, 2022 Non-steroidal anti-inflammatory drugs (NSAIDs) are considered in cancer therapy for their inhibitory effect on cyclooxygenase-2 (COX-2), which is overexpressed in most cancers. However, we found that NSAIDs as ligands of peroxisome proliferator-activated receptor-γ (PPARγ)-induced apoptosis independent of the COX-2 inhibition, and the process was ...
Kazberuk A +4 more
europepmc +4 more sources
Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. [PDF]
Oncotarget, 2018 Proline degradation by proline dehydrogenase/proline oxidase (PRODH/POX) contributes to apoptosis or autophagy. The identification of specific pathway of apoptosis/survival regulation is the aim of this study. We generated knocked-down PRODH/POX MCF-7 breast cancer cells (MCF-7shPRODH/POX). PRODH/POX silencing did not affect cell viability. However, it
Zareba I +4 more
europepmc +4 more sources
Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line. [PDF]
Int J Mol Sci, 2022 The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells. PRODH/POX is a mitochondrial enzyme-degrading proline that is implicated in the regulation of cancer cell survival/apoptosis. The enzyme is activated by AMP kinase (AMPK). It has been found that
Oscilowska I +10 more
europepmc +5 more sources
PPARgamma and Proline Oxidase in Cancer. [PDF]
PPAR Res, 2008 Proline is metabolized by its own specialized enzymes with their own tissue and subcellular localizations and mechanisms of regulation. The central enzyme in this metabolic system is proline oxidase, a flavin adenine dinucleotide‐containing enzyme which is tightly bound to mitochondrial inner membranes.
Phang JM, Pandhare J, Zabirnyk O, Liu Y.
europepmc +4 more sources
Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids [PDF]
FEBS Open BioThis study investigated the reactivity of sarcosine oxidase (Sox) toward minor substrates through kinetic and structural analyses, along with mutational engineering to elucidate their reaction mechanisms. Sarcosine oxidase from Bacillus sp.
Yuqi Zhang +5 more
doaj +2 more sources
Polyethylene glycol and proline synergistically improve salinity tolerance via physiological and biochemical reprogramming in mango [PDF]
BMC Plant BiologyBackground Mango (Mangifera indica L.) is a globally important fruit crop, but its sensitivity to salt stress poses a serious threat to its sustainable cultivation.
Mohamed El Kheshin, Ibrahim Hmmam
doaj +2 more sources