Results 111 to 120 of about 28,951 (151)
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Proline oxidase in cultured mammalian cells
Journal of Cellular Physiology, 1977AbstractWe sought a cultured cell line with Proline Oxidase activity to study the regulation and physiologic role of the enzyme in mammalian tissues. Among the cell lines tested, only LLC‐RK1 cells, derived from rabbit kidney, had significant Proline Oxidase activity; the Km for proline of the enzyme from these cells was similar to that for the liver ...
S J, Downing +4 more
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Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis
Molecular and Cellular Biochemistry, 2006Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). Previously we showed that overexpression of POX is associated with generation of reactive oxygen species (ROS) and apoptosis in POX-inducible colorectal cancer cells, DLD-1.POX.
Chien-an A, Hu +8 more
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Characteristics of proline oxidase in rat tissues.
Journal of biochemistry, 1980In adult rats the activity of proline oxidase is high in the liver and kidney and moderate in the brain and heart, but it is not detectable in the lung, skeletal muscle, spleen, or small intestine. The activity in the liver is 1.5 times higher in females than males.
Y, Kawabata, N, Katunuma, Y, Sanada
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Proline Oxidase (POX) as A Target for Cancer Therapy
Current Drug Targets, 2015Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated. POX is widely distributed in living organisms and is responsible for a number of regulatory processes such as redox homeostasis, osmotic adaptation, cell signaling and oxidative stress.
Joanna, Kononczuk +5 more
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BioFactors, 2016
AbstractProlidase is a cytosolic imidodipeptidase that specifically splits imidodipeptides with C‐terminal proline or hydroxyproline. The enzyme plays an important role in the recycling of proline from imidodipeptides for resynthesis of collagen and other proline‐containing proteins.
Ilona, Zareba, Jerzy, Palka
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AbstractProlidase is a cytosolic imidodipeptidase that specifically splits imidodipeptides with C‐terminal proline or hydroxyproline. The enzyme plays an important role in the recycling of proline from imidodipeptides for resynthesis of collagen and other proline‐containing proteins.
Ilona, Zareba, Jerzy, Palka
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Glucocorticoid induction of proline oxidase in LLC‐RK1 cells
Journal of Cellular Physiology, 1978AbstractDexamethasone induced proline oxidase in cultured LLC‐RK1 cells, an epithelial cell line derived from rabbit kidney. The dexamethasone‐mediated increase in enzyme activity was concentration and time dependent. Although the effect could be dissociated from cell growth and cell density, it was dependent on protein and RNA synthesis.
E M, Kowaloff +3 more
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Proline oxidase inhibition by free fatty acids of rat pancreas
Biochimica et Biophysica Acta (BBA) - Enzymology, 1980Proline oxidase activity was not measurable in pancreas homogenate but was measurable in pancreas slices. Moreover, added pancreas homogenate inhibited proline oxidase activity in rat liver mitochondria and several other tissues. The partially purified inhibitor from pancreas also inhibited the activity of glutamate, glucose 6-phosphate, NADH and ...
H, Kadowaki, G M, Patton, W E, Knox
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Proline reduces brain cytochrome c oxidase: prevention by antioxidants
International Journal of Developmental Neuroscience, 2007AbstractIn the present study, we initially investigated the in vivo (acute and chronic) and in vitro effects of proline on cytochrome c oxidase (complex IV) activity in rat cerebral cortex to test the hypothesis that proline might alter energy metabolism and that this alteration could be provoked by oxidative stress.
Daniela, Delwing +4 more
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The Journal of Parasitology, 1974
The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
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The source was sought for the high levels of proline observed in the bile of animals infected with Fasciola hepatica. Toward this end the activities of 2 key enzymes in the metabolism of proline were measured. Ornithine-4-transaminase was compared in homogenates of Fasciola, rabbit liver, and rat liver.
J, Ertel, H, Isseroff
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Pyrroline-5-Carboxylate Reductase and Proline Oxidase Activity in the Neonatal Pig
The Journal of Nutrition, 1989Recent evidence suggests that proline is an indispensible amino acid in the diet of the young pig. A dietary requirement may relate to the activity and developmental changes of the enzymes that synthesize and degrade proline. The activity of pyrroline-5-carboxylate (P5C) reductase (EC 1.5.1.2), which catalyzes the final step in proline synthesis, and ...
S E, Samuels, K S, Acton, R O, Ball
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