Results 121 to 130 of about 263,845 (214)

Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle

Cells
Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice.
Natalia F. Zakirova, Olga A. Khomich, Olga A. Smirnova, Jennifer Molle, Sarah Duponchel, Dmitry V. Yanvarev, Vladimir T. Valuev-Elliston, Lea Monnier, Boyan Grigorov, Olga N. Ivanova, Inna L. Karpenko, Mikhail V. Golikov, Cedric Bovet, Barbara Rindlisbacher, Alex R. Khomutov, Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov   +17 more
doaj   +1 more source

Stress‐specific metabolic and physiological responses to drought and waterlogging in Allium cepa L. and Allium × cornutum Clementi ex Vis.

Plant Biology, Volume 28, Issue 7, Page 2204-2216, December 2026.
Drought and waterlogging induce distinct species‐specific metabolic, physiological and transcriptional responses in Allium cepa and Allium × cornutum. Abstract Increasing variability in water availability, caused by changing climatic conditions, is a major constraint for onion production.
Ž. Fredotović, B. Soldo, B. Urlić, K. Radovani, E. Vuko, J. Puizina   +5 more
wiley   +1 more source

Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile

The Scientific World Journal, 2014
This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were ...
Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov   +7 more
doaj   +1 more source

Biosynthetic Pathways and Regulation of Antibacterial Compounds From Endophytic Fungi: From Chemistry to Genomics and Biotechnology

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Endophytic fungi encode abundant cryptic biosynthetic gene clusters that remain largely silent under conventional cultivation. This review highlights how genome mining, multi‐omics, and cluster activation strategies bridge the BGC‐to‐metabolite gap, enabling the discovery of structurally diverse antibacterial natural products with activity against ...
Farkhod Eshboev, Abubakar Siddiq Salihu, Lobar Khayrullaeva, Doniyor Khamdamov, Alex X. Gao, Kamila Mardieva, Wan Mohd Nuzul Hakimi Wan Salleh, Shakhnoz Azimova, Karl W. K. Tsim   +8 more
wiley   +1 more source

Capillary array electrophoresis for the research of asymmetric transformation reaction of L-proline to D-proline

, 2005
One asymmetric transformation reaction Of L-proline (L-Pro) to D-proline was studied by a home-made capillary array electrophoresis (CAE) for the first time.
王利, Liu, KY, Wang, J, Wang, L, Sun, GM, Bai, JL   +5 more
core   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

An SH3 domain and proline-rich sequence mediate an interaction between 2 components of the phagocyte NADPH oxidase complex

, 1994
Neutrophils possess a multicomponent NADPH oxidase system capable of producing large quantities of superoxide in a process known as the respiratory burst (1).
Finan, Peter, Waterfield, Michael D., Gout, Ivan, Bennett, Paul, Kellie, Stuart, Butcher, Christopher, Shimizu, Yazuaki, Hsuan, Justin, Truong, Oanh   +8 more
core  

Enhancement of postharvest longan fruit quality through chitosan (CTS)-induced modulation of energy and proline metabolism

Scientific Reports
Chitosan (CTS), a biologically safe preservative, is crucial for post-harvest treatment of fruit and vegetables, yet its regulatory mechanisms remain poorly understood. Our research on various CTS concentrations in longan fruit post-harvest showed that 1.
Xinmin Lv, Yulian Li, Jiaying Chen, Shilian Huang, Junbin Wei, Shiya Xu, Dongliang Guo, Yan Zhou   +7 more
doaj   +1 more source

Weather induced physiological responses on the flowering habits of neem trees (Azadirachta indica)

Journal of Agrometeorology
Adaptability and significant economic value of the neem tree are well-known, as it can flourish in a variety of environmental conditions. While the neem seed production is highly sensitive to prevailing weather conditions during the reproductive phase ...
R. BALASREE, GA. DHEEBAKARAN, A. SENTHIL, N.K. SATHYAMOORTHY, PATIL SANTOSH GANAPATI, K. PUGAZENTHI   +5 more
doaj   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9809-9818, November 2026.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source