Results 91 to 100 of about 28,299 (224)

The Cell-Penetrating Peptide GV1001 Enhances Bone Formation via Pin1-Mediated Augmentation of Runx2 and Osterix Stability

Biomolecules
Peptide-based drug development is a promising direction due to its excellent biological activity, minimal immunogenicity, high in vivo stability, and efficient tissue penetrability.
Meiyu Piao, Sung Ho Lee, Jin Wook Hwang, Hyung Sik Kim, Youn Ho Han, Kwang Youl Lee   +5 more
doaj   +1 more source

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

Cell Reports, 2015
Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood.
Martin Balastik, Xiao Zhen Zhou, Meritxell Alberich-Jorda, Romana Weissova, Jakub Žiak, Maria F. Pazyra-Murphy, Katharina E. Cosker, Olga Machonova, Iryna Kozmikova, Chun-Hau Chen, Lucia Pastorino, John M. Asara, Adam Cole, Calum Sutherland, Rosalind A. Segal, Kun Ping Lu   +15 more
doaj   +1 more source

Accumulation of properly folded human type III procollagen molecules in specific intracellular membranous compartments in the yeast Pichia pastoris [PDF]

, 2000
It was recently reported that co-expression of the proal(III) chain of human type III procollagen with the subunits of human prolyl 4-hydroxylase in Pichia pastoris produces fully hydroxylated and properly folded recombinant type III procollagen ...
Keizer-Gunnink, [No Value], Keizer-Gunnink, Ineke, Kivirikko, Kari I., Kivirikko, KI, Myllyharju, J, Pihlajaniemi, T, Veenhuis, M, Vuorela, A   +7 more
core   +2 more sources

Time‐Resolved Transcriptomics Reveal Core and Genotype‐Specific Pathways Underlying Thermotolerance in Wheat

Food and Energy Security, Volume 15, Issue 2, March/April 2026.
ABSTRACT Heat stress increasingly threatens global wheat production as extreme temperature events become more frequent under climate change. To better understand the molecular basis of thermotolerance, we evaluated the heat responses of 30 elite wheat accessions and identified substantial natural variation in seedling survival (26.7%), plant height (26.
Junlong Jiang, Zehao Hou, Shuping Wang, Yingxin Zhang, Dongfang Ma, Yuting Li, Zhengwu Fang   +6 more
wiley   +1 more source

Rrd1 isomerizes RNA polymerase II in response to rapamycin [PDF]

, 2010
International audienceBACKGROUND: In Saccharomyces cerevisiae, the immunosuppressant rapamycin engenders a profound modification in the transcriptional profile leading to growth arrest.
Nathalie Jouvet, Jeremie Poschmann, Julie Douville, Lisa Bulet, Dindial Ramotar   +4 more
core   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, Volume 3, Issue 1, Page 47-68, March 2026.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

PIN1 in Cell Cycle Control and Cancer

Frontiers in Pharmacology, 2018
Cell cycle progression is tightly controlled by many cell cycle-regulatory proteins that are in turn regulated by a family of cyclin-dependent kinases (CDKs) through protein phosphorylation. The peptidyl-prolyl cis/trans isomerase PIN1 provides a further
Chi-Wai Cheng, Eric Tse
doaj   +1 more source

Effect of cyclosporine on hepatic energy status and on fructose metabolism after portacaval shunt in dog as monitored by phosphorus‐31 nuclear magnetic resonance spectroscopy in vivo [PDF]

, 1991
The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus‐31 nuclear magnetic resonance spectroscopy in dogs.
Atkinson, Avison, Baldassarri, Bode, Bäckman, Calne, Cohen, Evelhoch, Francavilla, Grant, Harder, Iles, Iles, Kahn, Kim, Kim, Klintmalm, Laupacis, Loertscher, Lorber, Makowka, Mazzaferro, Otte, Powles, Roos, Rossaro, Schade, Seo, Stacey, Starzl, Starzl, Starzl, Starzl, Starzl, Stone, Thompson, Van Thiel, Ziegler   +37 more
core   +1 more source

Regulation of tau by peptidyl-prolyl isomerases

Current Opinion in Structural Biology
Tau is an intrinsically disordered protein found abundantly in axons, where it binds to microtubules. Since tau is a central player in the dynamic microtubule network, it is highly regulated by post-translational modifications. Abnormal hyperphosphorylation and aggregation of tau characterize a group of diseases called tauopathies.
Shannon Zhuang, Pijush Chakraborty, Markus Zweckstetter   +2 more
openaire   +4 more sources

Effect of MF3 (peptidyl-prolyl cis/trans isomerase) protein from Pseudomonas fluorescens on ex vitro adaptation and post-adaptation of hardy kiwi (Actinidia arguta Planch. ex Miq.) plants [PDF]

BIO Web of Conferences
The effect of bacterial protein (peptidyl-prolyl cis/trans isomerase) in different concentrations on ex vitro adaptation and post-adaptation of Actinidia arguta Planch. ex Miq. plants of cultivar Geneva was investigated. The results indicating the growth-
Sergeeva Kseniia, Nechiporenko Ivan, Popletaeva Sophya   +2 more
doaj   +1 more source