Results 101 to 110 of about 18,044 (216)
, 2021 Attenuated intracellular survival of Mycobacterium tuberculosis (Mtb) secretory gene mutants exemplifies their role as virulence factors. Mtb peptidyl prolyl isomerase A (PPiA) assists in protein folding through cis/trans isomerization of prolyl bonds ...
Dubey, Neha +7 more
core +1 more source
, 2012 [[abstract]]The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt ...
Liao, Y.;Wei, Y;Zhou, Z;Yang, J-Y;Dai, C;Chen, Y-J;Agarwal, N.K;Sarbassov, D;Shi, D;Yu, D;洪明奇;Hung, Mien-Chie
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The Prolyl Isomerase Pin1 in Breast Development and Cancer [PDF]
, 2011 The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer.
Ryo, Akihide +3 more
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FRET-Protease-Coupled Peptidyl-Prolyl cis-trans Isomerase Assay [PDF]
, 2016 In this work, a sensitive and convenient protease-based fluorimetric high-throughput screening (HTS) assay for determining peptidyl-prolyl cis-trans isomerase activity was developed. The assay was based on a new intramolecularly quenched substrate, whose
Doti, Nunzianna +7 more
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Characterising the expression and interactions of the Endoplasmic Reticulum Oxidoreductase Erol β [PDF]
, 2006 Proteins destined for the secretory pathway and endoplasmic reticulum (ER) resident proteins are targeted to the ER through an N-terminal signal sequence. Proteins then follow a post-translational maturation process to fold into functional proteins.
Gunasekara, Sanjika Dias
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Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation
, 2015 Infectious agents develop intricate mechanisms to interact with host cell pathways and hijack the genetic and epigenetic machinery to change phenotypic states.
Chluba, J. +13 more
core +1 more source
, 2016 The peptidyl prolyl cis/trans isomerase Pin1 has been implicated in the development of cancer, Alzheimer's disease and asthma, but highly specific and potent Pin1 inhibitors remain to be identified.
Gerlind Stoller (2644891) +8 more
core +1 more source
Activation of colicin M by the FkpA prolyl cis-trans isomerase/chaperone
, 2011 Colicin M (Cma) is specifically imported into the periplasm of Escherichia coli and kills the cells. Killing depends on the periplasmic peptidyl prolyl cis-trans isomerase/chaperone FkpA. To identify the Cma prolyl bonds targeted by FkpA, we replaced the
Schiene-Fischer, C. +10 more
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Characterisation of human peptidyl prolyl isomerase-like protein 1 (PPIL1) mutations [PDF]
, 2019 A novel brain malformation syndrome was previously reported in six individuals from four families. Patients presented with profound microcephaly (OFC 7-9 SD < mean), severe cortical dysplasia, profound cerebellar hypoplasia of both vermis and hemispheres
Webb, Alice Elizabeth
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, 2006 The peptidyl prolyl cis/trans isomerase Pin1 has been implicated in the development of cancer, Alzheimer's disease and asthma, but highly specific and potent Pin1 inhibitors remain to be identified.
Schutkowski, M. +8 more
core +1 more source