Results 41 to 50 of about 28,299 (224)
MoleculesMany folding enzymes use separate domains for the binding of substrate proteins and for the catalysis of slow folding reactions such as prolyl isomerization. FKBP12 is a small prolyl isomerase without a chaperone domain.
Gabriel Žoldák +6 more
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Rescue of conformational dynamics in enzyme catalysis by directed evolution
Nature Communications, 2018 A key challenge in the field of protein design and evolution is to understand the mechanisms by which directed evolution is improving enzymes. Here the authors combine different biophysical methods and give mechanistic insights into how directed ...
Renee Otten +7 more
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Molecules, 2008 The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been madeaccessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclicbenzofuranones 2 and 3, respectively.
Gunter Fischer +4 more
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The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin [PDF]
, 1993 The cytosolic peptidyl-prolyl cis/trans isomerase cyclophilin from pig kidney can accelerate catalytically the cis/trans isomerization of prolyl peptide bonds.
Fischer +23 more
core +1 more source
FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth
Cell Reports, 2020 Summary: Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isomerase (
Giorgio Ramadori +17 more
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Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. [PDF]
PLoS Biology, 2010 Peptidyl-prolyl isomerases catalyze the conversion between cis and trans isomers of proline. The cyclophilin family of peptidyl-prolyl isomerases is well known for being the target of the immunosuppressive drug cyclosporin, used to combat organ ...
Tara L Davis +11 more
doaj +1 more source
Cyclophilin-A is bound to through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex [PDF]
, 2004 Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known.
Galigniana, Mario Daniel +3 more
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Neoplasia: An International Journal for Oncology Research, 2002 Microtubule inhibitor-induced Bcl2 phosphorylation is detrimental to its antiapoptotic function. Phosphorylation of Bcl2 predominantly occurs on two serine residues (70 and 87) in cells arrested at G2-M phase by microtubule disarraying agents.
Aruna Basu +5 more
doaj +1 more source
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis
Nature Communications, 2021 The most frequent cause of familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are hexanucleotide repeat expansions in the non-coding region of the C9ORF72 gene that are translated into five dipeptide repeat (DPR) proteins ...
Maria Babu +5 more
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A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]
, 2016 Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I +2 more
core +1 more source