Results 51 to 60 of about 28,299 (224)

Improved proteomic analysis of nuclear proteins, as exemplified by the comparison of two myelo\"id cell lines nuclear proteomes [PDF]

, 2012
One of the challenges of the proteomic analysis by 2D-gel is to visualize the low abundance proteins, particularly those localized in organelles. An additional problem with nuclear proteins lies in their strong interaction with nuclear acids.
Chevallet, Mireille, Diemer, Hélène, Lelong, Cécile, Luche, Sylvie, Rabilloud, Thierry, Van Dorsselaer, Alain   +5 more
core   +4 more sources

Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells

Cell Reports, 2018
Summary: The SRC-family kinase LYN is highly expressed in triple-negative/basal-like breast cancer (TNBC) and in the cell of origin of these tumors, c-KIT-positive luminal progenitors.
Giusy Tornillo, Catherine Knowlson, Howard Kendrick, Joe Cooke, Hasan Mirza, Iskander Aurrekoetxea-Rodríguez, Maria d.M. Vivanco, Niamh E. Buckley, Anita Grigoriadis, Matthew J. Smalley   +9 more
doaj   +1 more source

Creation of a Pseudotsuga menziesii nucellus cell suspension culture system to produce proteins involved in reproduction

Applications in Plant Sciences, EarlyView.
Abstract Premise Cell suspension cultures of Douglas‐fir (Pseudotsuga menziesii) nucellus were created to overcome phenological limitations to the in situ study of bioactive proteins within and secreted by nucellar cells. Methods Proteins isolated from the cell suspension culture medium were analyzed using mass spectrometry, as were Douglas‐fir post ...
Andrea Coulter, YuQi Li, Julia Lakhani, Natalie Prior, Patrick von Aderkas   +4 more
wiley   +1 more source

A Family of Novel Cyclophilins, Conserved in the Mimivirus Genus of the Giant DNA Viruses

Computational and Structural Biotechnology Journal, 2018
The cyclophilin (abbreviated here as CYN) family represents a large group of protein prolyl isomerase (PPIase), many of which are also chaperones that promote proper folding of a large variety of client proteins. Over the past few years, megaviruses with
Sailen Barik
doaj   +1 more source

Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2020
Alzheimer’s disease (AD) is the most common cause of dementia with cognitive decline. The neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles consisting of hyperphosphorylated tau and extracellular deposition of ...
Long Wang, Ying Zhou, Ying Zhou, Dongmei Chen, Tae Ho Lee   +4 more
doaj   +1 more source

FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion [PDF]

, 1993
Using a rat model, the effect of pre-treatment with FK 506 on hepatic ischemia/reperfusion injury was investigated. All control animals died within 72 h of the ischemia/reperfusion injury.
Aarden, Billiau, Camussi, Chollet-Martin, Colletti, Colletti, Craig J. McClain, David H. Van Thiel, Farber, Ferrante, Fischer, Francavilla, Francavilla, Gamble, Gauldie, Giorgio M. Zetti, Hajjar, Harding, Hayashi, Hishinuma, Honchel, Howard, Jirik, Judith S. Gavaler, Kahan, Kahn, Kawakani, Kim, Kim, Kino, Kishimoto, Kishimoto, Kramer, Lotz, Magilavy, Mahmoud F. Sakr, Makowka, Makowka, Matuschak, Maury, Mazzaferro, Meer, Miyahara, Mizel, Nagakawa, Nagakawa, Nawroth, Nordan, Nordan, Pennica, Perez-Tamayo, Pohlman, Sakai, Sakr, Shalaby, Shaw, Siekierka, Starzl, Starzl, Strieter, Takahashi, Thomas E. Starzl, Van Snick, Wankowicz, Yushimira   +64 more
core   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Prolyl Isomerase Pin1 is Highly Expressed in Her2-Positive Breast Cancer and Regulates erbB2 Protein Stability [PDF]

, 2013
Overexpression of HER-2/Neu occurs in about 25–30% of breast cancer patients and is indicative of poor prognosis. While Her2/Neu overexpression is primarily a result of erbB2 amplification, it has recently been recognized that erbB2 levels are also ...
Burga, Laura N, Hofstatter, Erin W, Lam, Prudence Bonita, Lu, Kun Ping, Wu, Bryan P, Wulf, Gerburg Maria   +5 more
core   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, EarlyView.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Comparative proteomic profiling reveals molecular characteristics associated with oogenesis and oocyte maturation during ovarian development of Bactrocera dorsalis (Hendel) [PDF]

, 2017
Time-dependent expression of proteins in ovary is important to understand oogenesis in insects. Here, we profiled the proteomes of developing ovaries from Bactrocera dorsalis (Hendel) to obtain information about ovarian development with particular ...
Wei, Dong, Li, Ran, Zhang, Meng-Yi, Liu, Yu-Wei, Zhang, Zheng, Smagghe, Guy, Wang, Jin-Jun   +6 more
core   +1 more source