Results 21 to 30 of about 902 (153)
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis [PDF]
Journal of Neuroinflammation, 2010 Abstract Background Multiple sclerosis (MS) is a complex, inflammatory and neurodegenerative disease of the central nervous system leading to long-term disability. Recent studies indicate a close association between inflammation and neurodegeneration in all lesions and disease stages of MS. Prolyl oligopeptidase (POP)
Tenorio-Laranga, Jofre +4 more
openaire +4 more sources
Journal of Neurochemistry, Volume 169, Issue 12, December 2025.The Ndel1 protein is crucial for neurodevelopment, but its role in the brain peptidome is unknown. Here we compared the peptidome of Ndel1 conditional knockout (Ndel1_cKO) mice with controls (CTRL) in four brain regions. Peptides were extracted using acidic (Acetic Acid, AcOH) and organic (Methanol, MeOH) methods and analyzed by Liquid Chromatography ...
João V. Nani +9 more
wiley +1 more source
Protein Science, Volume 34, Issue 11, November 2025.Abstract Acylpeptide hydrolase (APEH) or acylaminoacyl‐peptidase (AAP) is a serine hydrolase that regulates protein metabolism. It can also bind to and process unusual substrates, acting as a detoxifier. To better understand its promiscuous specificity, we determined the cryo‐EM structures of mammalian APEH complexed with classical serine protease ...
Anna J. Kiss‐Szemán +8 more
wiley +1 more source
Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics [PDF]
Cell Chemical Biology, 2018 Prolyl oligopeptidase (POP), a serine protease highly expressed in the brain, has recently emerged as an enticing therapeutic target for the treatment of cognitive and neurodegenerative disorders. However, most reported inhibitors suffer from short duration of action, poor protease selectivity, and low blood-brain barrier (BBB) permeability, which ...
Guardiola Bagán, Salvador +8 more
openaire +5 more sources
The Plant Genome, Volume 18, Issue 3, September 2025.Abstract Stem rot, caused by Sclerotium rolfsii Sacc., is a devastating soil‐borne disease causing up to 80% yield losses in groundnut globally. To dissect the genetic basis of resistance, we evaluated a diverse minicore germplasm panel over 3 years in stem rot sick‐field conditions.
H. V. Veerendrakumar +11 more
wiley +1 more source
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson’s Disease [PDF]
, 2023 Tommi Kilpeläinen +12 more
openalex +1 more source
Twenty years of therapeutic development in tauopathy mouse models: a scoping review
Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract Tauopathies are neurodegenerative diseases characterized by pathological tau protein inclusions and dementia. Tauopathy mouse models with MAPT mutations replicate tau‐related pathologies and are widely used for therapeutic research. This scoping review examines 409 treatment evaluations in MAPT mouse models.
Vanessa F. Langness +8 more
wiley +1 more source
Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus [PDF]
FEBS Letters, 2006 Prolyl oligopeptidase (POP), the paradigm of a serine peptidase family, hydrolyses peptides, but not proteins. The thermophilic POP from Pyrococcus furiosus (Pfu) appeared to be an exception, since it hydrolysed large proteins. Here we demonstrate that the Pfu POP does not display appreciable activity against azocasein.
Juhász, Tünde +2 more
openaire +2 more sources
Designing Enzymatic Reactivity with an Expanded Palette
ChemBioChem, Volume 26, Issue 11, June 3, 2025.Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley +1 more source